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science nutrition <strong>blog</strong>

Let’s face it, losing weight is TOUGH. Whether you struggle with overeating, having a slow metabolism, or lacking the motivation to hit the gym, the battle against the bulge is never easy.

But, all hope is not lost as modern science has uncovered a powerful compound that revs up metabolism, suppresses appetite, and even enhances performance. Sounds too good to be true, doesn’t it?

Well, then it’s time you learned a little more about Advantra Z® and we’ve got the full scoop for you ahead!

What is Advantra Z®?

Developed by Nutratech Inc, Advantra Z® is a patented extract of Citrus Aurantium (a.k.a. Bitter Orange), a fruit rich in a number of alkaloids known to enhance weight loss. Bitter orange has a long history of use in Chinese medicine as a remedy for a number of GI problems including indigestion, nausea, and even constipation. Additionally, various South American cultures have used to to reduce symptoms of anxiety or insomnia as well as treat convulsions.

Among the numerous alkaloids contained in Bitter Orange, p-synephrine is the one we’re most interested in for weight loss purposes. P-Synephrine is the most bioactive component of bitter orange and is where the fat burning and performance enhanced effects of Advantra Z® are!

Up Close with Synephrine

P-Synephrine is a thermogenic agent, similar to ephedrine or pseudoephedrine, though not quite as potent or as dangerous.[1] Similar to ephedrine, p-synephrine has been well documented to increase energy expenditure, decrease appetite, elevate resting metabolic rate (RMR), and enhance fat loss!

Classified as an adrenergic amine, p-synephrine stimulates the beta-3 receptors in the body with little to no effect on the other alpha or beta receptors. These beta-3 receptors are responsible the lipolytic and thermogenic (fat-burning and temperature raising) actions in the body, while the beta-1 & 2 receptors induce smooth muscle relaxation and excite (i.e. increase) cardiac muscle. As you can guess, it you’re interested in fat loss, you want as much activity from beta-3 receptors as possible with minimal effects from the beta-1 & 2 receptors, or even alpha receptors..

The primary benefit of beta-3 stimulation without beta-1 or 2 activity is that you effectively increase your metabolic rate increases without increasing your blood pressure or heart rate, an ideal recipe for safe and effective fat loss. Plus, beta-3 stimulation also increases adrenaline and noradrenaline release, which kickstarts lipolysis, the breakdown and release of fatty acids into the bloodstream, a.k.a using fat for fuel!.

There’s still more to this powerful alkaloid, as p-synephrine also enhances glucose uptake in skeletal muscle, which further supports fat loss and muscle gain! Basically, p-synephrine helps remove excess glucose from the bloodstream and transports it into your muscle tissue instead of storing it in adipose (fat) tissue. Plus, by increasing muscle glucose, you’re provide an extremely efficient source of energy for your muscles which will increase exercise performance and endurance, yielding more intense workouts and greater calorie burn for rapid weight loss!

P-Synephrine synergizes with another popular stimulant, caffeine, and when the two are taken together (as they are in AML ThermoHeat), the end result is even greater energy, fatty acid mobilization, and appetite suppression!

Effective AND Safe

The great thing about p-synephrine (and Advantra Z®) is that it has over 30 studies documenting its efficacy and, more importantly, its safety for humans.[1,2]

Why Advantra Z®?

You’re probably wondering why you should supplement with Advantra Z®, which is a whole plant extract of Citrus Aurantium, instead of just plain p-synephrine?

Well, it’s more effective for fat burning!

Specifically, when p-synephrine is combined with naringin and hesperidin, two other compounds found in Citrus Aurantium, your metabolism burns an extra 180 calories over just regular p-synephrine on its own!.[3]

Benefits of Advantra Z®

  • Elevates resting metabolic rate (RMR)
  • Increases energy expenditure
  • Stimulates lipolysis
  • Suppresses appetite
  • Accelerates weight loss
  • Delays absorption of carbs and fats
  • Synergistic with caffeine
  • Heightens focus
  • Improves glucose storage and utilization
  • Supports cognitive function


Stubborn belly and booty fat doesn’t have to be a life sentence, at least not with the help of Advantra Z®! It’s an ideal ingredient to include in any fat burning stack and one of the primary reasons it’s the very first ingredient in AML ThermoHeat.

When looking for a safe and effective method for accelerating fat loss results, AML ThermoHeat featuring Advantra Z® is the choice each and every time.


1. Stohs SJ, Preuss HG, Shara M. A Review of the Human Clinical Studies Involving Citrus aurantium (Bitter Orange) Extract and its Primary Protoalkaloid p-Synephrine. International Journal of Medical Sciences. 2012;9(7):527-538. doi:10.7150/ijms.4446.
2. Lopez HL, Ziegenfuss TN, Hofheins JE, et al. Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women. Journal of the International Society of Sports Nutrition. 2013;10:22. doi:10.1186/1550-2783-10-22.
3. Stohs SJ, Preuss HG, Keith SC, Keith PL, Miller H, Kaats GR. Effects of p-Synephrine alone and in Combination with Selected Bioflavonoids on Resting Metabolism, Blood Pressure, Heart Rate and Self-Reported Mood Changes. International Journal of Medical Sciences. 2011;8(4):295-301.