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science nutrition blog

science nutrition <strong>blog</strong>

By Robert Schinetsky


Coffee is fantastic.

Theres a reason why millions upon millions of people around the world start their day with a cup (or French Press full) of the stuff.

Coffee is warm and comforting. It’s loaded with polyphenols and antioxidants, and it contains caffeine.

Moreover, theres been a trend in epidemiological studies pointing to an increased lifespan and reduced risk of various illnesses with greater intakes of coffee.[1,2,3]

For those worried about the caffeine content of coffee, theres good news. Research indicates that higher intakes of decaffeinated coffee are also associated with a lower risk of total mortality.[3]

As great as coffee is in its own right, there’s been a strange trend adopted by bio-hackers, low-carb enthusiasts, and other self-proclaimed “gurus” to try and make coffee even better through the addition of butter.

The claims are far and wide, but they usually center around one (or more) of the following:

  • Boosting metabolism
  • Reducing hunger
  • Increasing fat burning
  • Stimulating ketogenesis
  • Enhancing cognitive function
  • Making you impervious to a zombie apocalypse


That last point might be a bit of an exaggeration, but read enough of the hype around butter coffee and youll sweat that youre invincible.

The reality is that mixing butter into a cup of coffee is a great way to ruin a perfectly fine beverage. Depending on how heaping a helping of butter you mix into your coffee, youre looking at taking a beverage that on its own (i.e. black coffee) contains between 5-10 calories and creating a fat-bomb containing upwards of 300-400 calories and dozens of grams of saturated fat! More often than not, these calories are consumed in addition to an individuals daily calorie intake.

This hardly seems like a savvy move for an individual trying to lose weight.

Now, the truly ardent supporters of butter coffee will say that you “must'' use unsalted, grass-fed butter as well as medium-chain triglyceride oil (MCT) as it's the magic of MCTs that’s really providing the alleged superpowers. Butter, while delicious, contains a lot of saturated fat, and while consuming some, there’s a big difference between using a little pat of butter to cook your eggs in the morning and swirling 2-3 tablespoons worth of it into your morning coffee (in addition to whatever other butter you may use to cook with during the day).

Theres also no considerable body of evidence indicating that adding butter to your coffee potentiates or enhances the already well-documented benefits of caffeine and coffee:

  • Appetite suppression
  • Increased metabolism
  • Heightened alertness
  • Enhanced exercise performance (which helps burn more calories)
  • Brown fat thermogenesis[19,20]


All of this is to say that if you are looking for something to add to your coffee, why not add something that actually offers science-backed benefits and tastes delicious?!

Thats exactly what Advanced Molecular Labs has created with Thermo Heat Protein.

What is Thermo Heat Protein?

Thermo Heat Fat Burning Protein is a scientifically-formulated protein and amino acid supplement created to help:

  • Enhance fat loss
  • Curb cravings
  • Preserve lean muscle mass


Each serving of AML ThermoHeat Fat Burning contains research-backed nutrients that promote thermogenesis, stimulate metabolism, reduce hunger, and protect skeletal muscle from the catabolic effects of low-calorie, low-carbohydrate diets.

Whats in Thermo Heat Fat Burning Protein?

MCT Oil Powder

We’ll begin with the ingredient that butter coffee (and all its derivations) are centered around -- MCT Oil.

MCTs are a special type of dietary fat that are more readily absorbed into the bloodstream compared to long-chain fatty acids (LCFAs). This provides a more efficient form of fatty fuel” for muscles compared to other types of fats since MCTs do not require a carnitine “taxi” to shuttle them into the mitochondria for β-oxidation.[4]

Another big plus of MCTs compared with other popular keto supplements (such as exogenous ketones) is that they stimulate the bodys endogenous production of ketone bodies as opposed to keto salts and esters that merely dump a bunch of ketones into the bloodstream but dont do much to stimulate the bodys ability to generate them. Moreover, MCTs have also been found to enhance the secretion of peptide YY and leptin -- two hormones that promote feelings of fullness[5,6]

Recently published research, appearing in the journal Nutrients, found that continuous ingestion of 2,000mg MCT increased fat oxidation during physical activity.[7] Previous studies have found that consuming a similar dose of MCTs increased postprandial thermogenesis and decreased body weight and body fat.[8,9]

AML Thermo Heat Fat Burning Protein supplies 3,000mg of MCTs per serving.

Muscle Preservation

Consuming enough protein is essential to preserving lean muscle mass during periods of dieting. However, many individuals struggle to consume adequate protein each day. At the same time, individuals following a ketogenic diet may need to be wary of consuming too much protein as doing so can temporarily kick them out of ketosis or make it take that much longer to enter into a state of nutritional ketosis.

Thermo Heat Protein addresses these myriad issues by using a combination of 6.25 grams of whey protein isolate + 5g of L-Leucine.

Why these specific numbers?

Research has shown that the addition of 5g of leucine to a suboptimal” dose of 6.25 grams of whey protein stimulated MPS to the same extent as an optimal (25 g) dose of whey protein.[10]

Furthermore, leucine is a ketogenic amino acid, and it’s metabolism leads to the formation of two important ketone bodies in acetoacetate and D-ß-hydroxy-butyrate (D-BHB).

Prior research has also found that the combination of MCTs (6 g), leucine-enriched amino acids (40% leucine in 3 grams of EAAs) and 800 IU Vitamin D3 may improve muscle strength and function in elderly individuals.[11]

FYI, Thermo Heat Fat Burning Protein supplies 3g MCTs, 5 grams of leucine, 6.25g of whey protein, and 1000IU of Vitamin D3.

Nitric Oxide + Brown Fat Activators

As part of the Thermo Heat family, you know that Thermo Heat Fat Burning Protein is going to include ingredients that stimulate brown fat thermogenesis.

We’ve already discussed MCTs, so let’s discuss some of the lesser-known nutrients that support fat burning -- nitric oxide precursors.

We all know (and love) the enhanced performance and pumps that nitric oxide support agents like L-Citrulline and grape skin polyphenols provide. But, it turns out that nitric oxide also has been shown to enhance brown adipose tissue (BAT or brown fat”) activity and thermogenesis.

Animal studies suggest that nitric oxide inhibits proliferation and enhances the expression of two key adipogenic marker genes in peroxisome proliferator-activated receptor (PPAR) and uncoupling protein-1 (UCP-1).[12,13]

PPAR-ɑ is a protein that stimulates fat breakdown in various tissue in the body, including brown fat, and it is activated during times of calorie restriction. Interestingly, PPAR-ɑ, and it plays a key role in ketogenesis.[14]

Other research in animals indicates that increased nitric oxide availability may reduce unfavorable changes in metabolism and gene expression associated with insulin resistance.[15]

Thermo Heat Fat Burning Protein utilizes a combination of L-Citrulline + grape skin extract to support nitric oxide production and enhance NO availability.

Paradoxine + BioPerine for Added Thermogenic Potency

Paradoxine is a well-known commodity in the world of weight loss supplements. This standardized grains of paradise extract (40mg) has been shown in humans to increase energy expenditure, improve body composition, and reduce visceral fat.[16,17]

To further enhance the thermogenic properties of Thermo Heat Fat Burning Protein as well as facilitate greater nutrient absorption and utilization, weve also included 5mg of the premium black pepper extract, BioPerine.

Piperine is the main alkaloid of black pepper and has been shown to activate the TRPV1 receptor, which triggers thermogenic energy expenditure.[18]

Electrolyte Support

Dieting is synonymous with feelings of lethargy, fatigue, and muscle cramping. This is especially common when an individual follows a low-carb or ketogenic diet.

Low-carb and ketogenic diets lead to a loss of glycogen and with that comes the elimination of water and essential electrolytes from the body.

To support hydration and proper electrolyte balance, AML Thermo Heat Fat Burning Protein includes both magnesium and potassium citrate, which not only offer great bioavailability but are also easy on the GI tract.


Coffee on its own is fantastic. And, if you like to drink your coffee black, then keep doing it!

But, if youre looking for something to mix into your coffee, or a fat burning keto coffee that not only enhances the taste but also supports your weight loss goals, then grab a tub of Thermo Heat Fat Burning Protein and whip up a fresh mug!



  1. Loftfield E, Cornelis MC, Caporaso N, Yu K, Sinha R, Freedman N. Association of Coffee Drinking With Mortality by Genetic Variation in Caffeine Metabolism: Findings From the UK Biobank. JAMA Intern Med. 2018;178(8):1086–1097. doi:10.1001/jamainternmed.2018.2425
  2. Park SY, Freedman ND, Haiman CA, Le Marchand L, Wilkens LR, Setiawan VW. Association of Coffee Consumption With Total and Cause-Specific Mortality Among Nonwhite Populations. Ann Intern Med. 2017 Aug 15;167(4):228-235. doi: 10.7326/M16-2472. Epub 2017 Jul 11. PMID: 28693036; PMCID: PMC7494322.
  3. Ding M, Satija A, Bhupathiraju SN, Hu Y, Sun Q, Han J, Lopez-Garcia E, Willett W, van Dam RM, Hu FB. Association of Coffee Consumption With Total and Cause-Specific Mortality in 3 Large Prospective Cohorts. Circulation. 2015 Dec 15;132(24):2305-15. doi: 10.1161/CIRCULATIONAHA.115.017341. Epub 2015 Nov 16. PMID: 26572796; PMCID: PMC4679527.
  4. Issues, N., & Gastroenterology, I. N. (2017). The Use of Medium-Chain Triglycerides, (February).
  5. St-Onge MP, Mayrsohn B, O'Keeffe M, Kissileff HR, Choudhury AR, Laferrère B. Impact of medium and long chain triglycerides consumption on appetite and food intake in overweight men. Eur J Clin Nutr. 2014;68(10):1134-40.
  6. Cliff J. d C. Harvey, Grant M. Schofield, Micalla Williden, and Joseph A. McQuillan, “The Effect of Medium Chain Triglycerides on Time to Nutritional Ketosis and Symptoms of Keto-Induction in Healthy Adults: A Randomised Controlled Clinical Trial,” Journal of Nutrition and Metabolism, vol. 2018, Article ID 2630565, 9 pages, 2018.
  7. Tsujino S, Nosaka N, Sadamitsu S, Kato K. Effect of Continuous Ingestion of 2 g of Medium-Chain Triglycerides on Substrate Metabolism during Low-Intensity Physical Activity. Nutrients. 2022;14(3):536. Published 2022 Jan 26. doi:10.3390/nu14030536
  8. Kasai M., Nosaka N., Maki H., Negishi S., Aoyama T., Nakamura M., Suzuki Y., Tsuji H., Uto H., Okazaki M., et al. Effect of dietary medium- and long-chain triacylglycerols (MLCT) on accumulation of body fat in healthy humans. Asia Pac. J. Clin. Nutr. 2003;12:151–160.
  9. Ogawa A., Nosaka N., Kasai M., Aoyama T., Okazaki M., Igarashi O., Kondo K. Dietary medium- and long-chain triacylglycerols accelerate diet-induced thermogenesis in humans. J. Oleo Sci. 2007;56:283– doi: 10.5650/jos.56.283.
  10. Churchward-Venne T, Breen L, Di Donato D, Hector A, Mitchell C, Moore DR, Stellingwerff T, Breuille D, Offord E, Baker S, Phillips S. 2014. Leucine supplementation of a low-protein mixed macronutrient beverage enhances myofibrillar protein synthesis in young men: a double-blind, randomized trial. Am J Clin Nutr 99(2):276–86
  11. Abe, S., Ezaki, O., & Suzuki, M. (2016). Medium-Chain Triglycerides in Combination with Leucine and Vitamin D Increase Muscle Strength and Function in Frail Elderly Adults in a Randomized Controlled Trial. The Journal of Nutrition, 146(5), 1017–1026. doi:10.3945/jn.115.228965
  12. Nisoli, E., & Carruba, M. O. (2006). Nitric oxide and mitochondrial biogenesis. Journal of Cell Science, 119(14), 2855 LP-2862.
  13. Engeli, S., Janke, J., Gorzelniak, K., Böhnke, J., Ghose, N., Lindschau, C., Sharma, A. M. (2004). Regulation of the nitric oxide system in human adipose tissue Increased eNOS, 45.
  14. Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B, Wahli W. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest. 1999;103(11):1489-98.
  15. Razny, U., Kiec-Wilk, B., Wator, L., Polus, A., Dyduch, G., Solnica, B., Dembinska-Kiec, A. (2011). Increased nitric oxide availability attenuates high fat diet metabolic alterations and gene expression associated with insulin resistance. Cardiovascular Diabetology, 10(1), 68.
  16. Sugita, J., Yoneshiro, T., et al; “Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men”; British Journal of Nutrition; (2013) 110(4), pp. 733–738;
  17. Sugita J, Yoneshiro T, et al; “Daily ingestion of grains of paradise (Aframomum melegueta) extract increases whole-body energy expenditure and decreases visceral fat in humans”; Journal of Nutritional Science and Vitaminology; 2014, 60(1): 22-27;
  18. McNamara FN, Randall A and Gunthorpe MJ. Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1). Br J Pharmacol 2005;144, 781-790.
  19. Velickovic K, Wayne D, Leija HAL, Bloor I, Morris DE, Law J, Budge H, Sacks H, Symonds ME, Sottile V. Caffeine exposure induces browning features in adipose tissue in vitro and in vivo. Sci Rep. 2019 Jun 24;9(1):9104. doi: 10.1038/s41598-019-45540-1. PMID: 31235722; PMCID: PMC6591281.
  20. Van Schaik L, Kettle C, Green R, Irving HR, Rathner JA. Effects of Caffeine on Brown Adipose Tissue Thermogenesis and Metabolic Homeostasis: A Review. Front Neurosci. 2021;15:621356. Published 2021 Feb 4. doi:10.3389/fnins.2021.621356