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Many aging adults use growth hormone (GH) and somatropin to increase muscle mass, decrease fat and improve the appearance of the skin. Some people experience growth hormone side effects such as numbness in the hands and feet, insulin resistance and joint pain. A review of literature by scientists from the University of Turin concluded that the best strategy for avoiding side effects is to begin with modest doses of approximately one to four milligrams per week. Growth hormone works mainly by increasing IGF-1 levels. IGF-1 provides a convenient method of accurately assessing the effective dose of growth hormone. Taking a more conservative approach minimizes side effects and maximizes the drug's effectiveness. For those considering human growth hormone injections, consulting with a healthcare provider is recommended. (European Journal of Endocrinology, published online November 14)