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Beta-hydroxy-beta-methylbutyrate (HMB) is a metabolite of the amino acid leucine. Some studies found that HMB prevented muscle protein breakdown, stimulated muscle growth and promoted fat breakdown. Krzysztof Durkalec-Michalski and Jan Jeszka from Poznan University in Poland found that 58 well-trained athletes taking three grams of HMB (the same amount found in Advanced Molecular Labs Muscle Growth Post-Workout Stack) daily for 12 weeks showed increases in maximal oxygen consumption and decreased fat mass, compared to a placebo (fake HMB). Creatine kinase— a marker of muscle breakdown— was also lower with HMB. HMB improves aerobic capacity, reduces body fat, prevents muscle breakdown and increases peak power output, so it would be an effective supplement for athletes.


(Journal Strength Conditioning Research, 30: 2617-2626, 2016)