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science nutrition blog

science nutrition <strong>blog</strong>

By Steve Blechman

 

A new study published August 12, 2020, in the Annals of Internal Medicine has shown for the first time that obesity in men, not women, is an independent risk factor for dying among COVID-19 patients. It is believed that men have more abdominal and visceral fat than women. Excess abdominal fat and visceral fat can increase the risk of metabolic syndrome, which can cause inflammation, insulin resistance, elevated blood sugar, diabetes, fatty liver disease, hypertension and cardiovascular disease.

A most recent study published June 23/30 2020, in the Journal of the American Medical Association (JAMA) reported, that 37% of the U.S. population has metabolic syndrome! It is a worldwide health issue and concern.

A healthy diet and lifestyle changes such as following the Mediterranean Diet along with exercise, has been shown in the scientific research to safely prevent and lower the risk of abdominal obesity and metabolic syndrome.

A randomized, cross-over study published January 7, 2019 in the Journal of the American College of Nutrition found that a short-term Mediterranean Diet can improve endurance exercise performance in as little as four days in men and women. 

The Mediterranean Diet is the healthiest diet, based on the latest scientific research. I have personally been a big advocate of the Mediterranean Diet for over 25 years. In 2018, U.S. News & World Report ranked the Mediterranean diet as the best overall diet for healthy eating, tied with the DASH diet. The Mediterranean diet was also ranked number one for the easiest diet to follow; best diet for diabetes; best heart-healthy diet and best plant-based diet too. U.S. News & World Report (January 2nd, 2019) selected the Mediterranean diet as the best overall diet and healthiest diet for 2019. It was also rated the best diet for preventing heart disease and diabetes. The keto diet was ranked 38 for overall diets! It was tied for first place for fast weight loss but not best in the long run because of the high amount of unhealthy saturated fats, which can raise the risk of cardiovascular disease. These results were based on a panel of 23 experts, and 41 diets based on the scientific literature. The expert panel consisted of the country’s top nutrition experts and physicians specializing in weight loss, diabetes, and cardiovascular disease.

A Harvard study published in the Journal of the American Medical Association (JAMA) on December 7, 2018, found a 25% reduction in cardiovascular risk on the Mediterranean diet! Finally, a study published in the International Journal of Cardiology on November 27, 2018 reported that the cholesterol-lowering statin drugs worked best when combined with a Mediterranean diet compared to statin drugs alone! Lowering inflammation and LDL (bad cholesterol) seems to be the likely synergistic benefit of combining the Mediterranean diet and statin drugs in people with cardiovascular disease and lowering mortality risk.

People who strictly follow the Mediterranean diet tend to have a lower body mass index (BMI), which is a measure of the proportion of weight to height and waist circumference – according to a large population study led by Simona Bertoli from the Nutritional Research Center in Milan, Italy. The Mediterranean diet is high in fish, seafood, antioxidant-rich vegetables, red wine and berries rich in polyphenols, beans, lentils, nuts, legumes and extra-virgin olive oil (EVOO) that are rich in healthy monounsaturated and polyunsaturated fats and low in saturated fats. Extra-virgin olive oil contains oleic acid, a monounsaturated fatty acid, and a polyphenol called oleuropein that can increase brown fat thermogenesis. Brown fat is a special kind of fat cell that generates heat and helps regulate bodyweight and energy expenditure. The body has two forms of fat – white fat and brown fat. Brown fat burns calories. The more brown fat you have, the more calories you burn. The capability of harnessing one’s brown fat for fat burning is revolutionary! The ability to get lean by producing extra brown fat and enhancing and activating existing brown fat represents a promising way to burn fat. Several landmark discoveries and approaches to this are being explored at major research centers and universities worldwide with great excitement. Brown fat research is a hot topic today! Studies indicate that the Mediterranean diet promotes metabolic health, boosts fat loss, prevents obesity and may increase longevity. (Clinical Nutrition, 2016; J of Nut Sci and Vitaminology, 2008; J Nutritional Biochemistry, 2017)

A breakthrough, long-term diet study was published in the American Heart Association journal Circulation on measuring body fat. This diet study used magnetic resonance imaging (MRI) technology for the first time, measuring changes in body and organ fat during 18 months on a Mediterranean/low-carb diet, with and without moderate physical exercise. MRI is a diagnostic technique that produces computerized images of organs and internal body tissues using a magnetic field and radio waves. This is the best approach to date for measuring body fat, compared to weighing people as a result of diet and exercise. The scale, skinfold calipers or underwater weighing aren’t giving you the whole picture.

The Mediterranean low-carb diet was significantly superior to a low-fat diet in decreasing fat storage, including visceral (deep abdominal) liver and heart fat. High visceral fat has been shown to increase metabolic syndrome, inflammation, cardiovascular disease and diabetes. Losing deep subcutaneous visceral fat, as well as hepatic (liver) fat, was associated with improved insulin sensitivity and improved lipid profile. In a groundbreaking, two-year dietary intervention study published in the New England Journal of Medicine, researchers found that the Mediterranean and low-carb diet was beneficial for weight loss. It appears to be just as safe, metabolically healthier and more effective for weight loss/fat loss compared to a low-fat diet. Consumption of monounsaturated fats (extra-virgin olive oil and nuts) is thought to improve insulin sensitivity, which may explain the favorable effect on blood glucose and insulin levels. Research has shown that nut consumption can enhance weight loss and weight gain (N Engl J Med, 2008)

The Mediterranean diet contains healthy fats from monounsaturated fats and is low in bad fats. Twenty-five years ago, nutritionists discouraged nut consumption because of their high fat content. Mountains of evidence show that nuts are a healthy food that reduces the risk of cardiovascular disease, cancer and all-cause mortality. A meta-analysis that combined the results of 20 studies involving more than 819,000 people, led by Dr. Dagfinn Aune from the Imperial College London, found that consuming 28 grams of nuts per day was linked to a reduced risk of coronary heart disease (29%), stroke (70%), cardiovascular disease (21%), total cancer risk (15%) and all-cause mortality (22%). Adding nut consumption to your daily diet can have a marked improvement on your health and prevention of disease. (BMC Medicine, 2016)

A study published in the European Journal of Nutrition cites nuts like walnuts, peanuts, pistachios and almonds to help increase weight loss and prevent obesity. Nuts are low in carbohydrates, are rich in fiber and are a good addition to the low-carb Mediterranean diet. (European Journal of Nutrition, 2017)

Fish consumption, rich in omega-3 fats that are found in oily fish like wild salmon, for instance, is a healthy component of the Mediterranean diet. The omega-3 fats in fish have been shown to activate brown fat thermogenesis and reduce waist circumference (Adipocyte, 2018). Numerous studies have demonstrated that fish oil lowers body fat and prevents fat accumulation in white adipose tissue (WAT) compared to other dietary oils. Fish oil intake can induce mitochondrial uncoupling protein (UCP1) expression in brown and beige adipocytes and thereby attenuate fat accumulation (Scientific Reports, 2015).

Regular salmon consumption is part of a heart-healthy diet. Ocean and wild fish are preferable over farmed fish. They are richer in omega-3 polyunsaturated fatty acids. For example, farmed tilapia is not a healthy fish because it is very low in omega-3 fatty acids and is rich in arachidonic acid, a polyunsaturated fatty acid that can increase inflammation and is linked to a higher risk of cardiovascular disease, cancer, metabolic syndrome and insulin resistance. Other rich food sources of arachidonic acid are found in beef, poultry, pork, butter, cream and egg yolks. Grass-fed beef is lower in arachidonic acid.

The book The Thermo Heat® Weight Loss Revolution by Michael Rudolph, Ph.D. provides a calorie-controlled low-carb Mediterranean diet, 30-day meal plan and exercise program. It says that you should limit yourself to 100 grams of carbohydrates per day, or less. Processed food and sugar is off the table! The Thermo Heat® Weight Loss Revolution stresses foods high in monounsaturated and omega-3 polyunsaturated fatty acids. It also recommends thermogenic brown fat-activating herbs and spices instead of salt to flavor food, such as garlic, onion, mustard and chili pepper (capsaicin), to name a few. Monounsaturated fats are more thermogenic than saturated fats found in high-fat dairy and red meat. Because of ease of compliance, The Thermo Heat® Weight Loss Revolution Mediterranean diet makes it easy to follow even when dining out. One or two glasses of polyphenol-rich red wine (not white wine, or any other alcoholic beverages) per day can have positive health benefits on the Mediterranean diet. Studies show that olive oil and certain spices can enhance brown fat and increase thermogenesis. A number of studies have shown that healthy fats from nuts, olive oil and fish, found predominantly in Italian, Greek and Turkish cuisine, have health benefits in the prevention of heart disease, type 2 diabetes, and obesity. Fish oil and omega-3 fats can decrease bodyweight gain and fat accumulation by increasing thermogenesis and energy expenditure. (Clinical Nutrition, 2009; Metabolism - Clinical and Experimental, 2008; International Journal of Obesity, 2002; Nutrition Journal, 2015).

For more authoritative information, see The Thermo Heat® Weight Loss Revolution, by Michael J. Rudolph, Ph.D, including the foreword by Daniel L. Friedman, MD and Eugene B Friedman, MD. You can click the link to order on Amazon here. The Thermo Heat®Weight Loss Revolution is a groundbreaking scientific plan based on research involving brown fat (BAT). The Thermo Heat® Weight Loss Revolution offers its readers a brown fat, thermogenic and brown-fat-activating-diet, nutrition, supplement(s) and exercise program.

 

References:

  1. Obesity and Mortality Among Patients Diagnosed With COVID-19: Results From an Integrated Health Care Organization. Sara Y. Tartof, Lei Qian, Vennis Hong, Rong Wei, Ron F. Nadjafi, Heidi Fischer, Zhuoxin Li, Sally F. Shaw, Susan L. Caparosa, Claudia L. Nau, Tanmai Saxena, Gunter K. Rieg, Bradley K. Ackerson, Adam L. Sharp, Jacek Skarbinski, Tej K. Naik, and Sameer B. Murali. Annals of Internal Medicine August 12th, 2020. 
  1. Hirode G, Wong RJ. Trends in the Prevalence of Metabolic Syndrome in the United States, 2011-2016. JAMA.2020;323(24):2526–2528. doi:10.1001/jama.2020.4501
  1. More than One-Third of Americans Have Dangerous Metabolic Syndrome. Moira McCarthy. Healthline. July 9, 2020
  1. Baker ME, DeCesare KN, Johnson A, Kress KS, Inman CL, Weiss EP. Short-Term Mediterranean Diet Improves Endurance Exercise Performance: A Randomized-Sequence Crossover Trial. J Am Coll Nutr. 2019;38(7):597-605. doi:10.1080/07315724.2019.1568322 
  1. Coronavirus War! Attack It Now: Potential Drugs and Treatment. Steve Blechman. April 1, 2020. Advanced Molecular Labs. Com https://advancedmolecularlabs.com/blogs/news/coronavirus-war-attack-it-now-potential-drugs-and-treatment 
  1. CORONAVIRUS RESEARCH: 500 More Clinicals! Hope On the Way!. Steve Blechman. April 10, 2020. Advanced Molecular Labs. https://advancedmolecularlabs.com/blogs/news/coronavirus-research-500-more-clinicals-hope-on-the-way 
  1. CORONAVIRUS PANDEMIC: HEALTH CRISIS WAR – FIGHT IT NOW! Steve Blechman. April 17, 2020. Advanced Molecular Labs. https://advancedmolecularlabs.com/blogs/news/coronavirus-pandemic-health-crisis-war-fight-it-now 
  1. Obesity Exacerbates the Cytokine Storm Elicited by Francisella tularensis Infection of Females and Is Associated with Increased Mortality. Mireya G. Ramos Muniz et al. June 26, 2018. Journal of Bio Med Rsch. 
  1. Richardson S, Hirsch JS, Narasimhan M, et al. Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. JAMA. Published online April 22, 2020. doi:10.1001/jama.2020.6775 
  1. Early peek at data on Gilead coronavirus drug suggests patients are responding to treatment.; By Adam Feuerstein @adamfeuerstein and Matthew Herper @matthewherper April 16, 2020 https://www.statnews.com/2020/04/16/early-peek-at-data-on-gilead-coronavirus-drug-suggests-patients-are-responding-to-treatment/ 
  1. Guo T, Fan Y, Chen M, et al. Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19). JAMA Cardiol.Published online March 27, 2020. doi:10.1001/jamacardio.2020.1017
  1. Madjid M, Safavi-Naeini P, Solomon SD, Vardeny O. Potential Effects of Coronaviruses on the Cardiovascular System: A Review. JAMA Cardiol.Published online March 27, 2020. doi:10.1001/jamacardio.2020.1286
  1. Bonow RO, Fonarow GC, O’Gara PT, Yancy CW. Association of Coronavirus Disease 2019 (COVID-19) With Myocardial Injury and Mortality. JAMA Cardiol.Published online March 27, 2020. doi:10.1001/jamacardio.2020.1105 
  1. Clinical Characteristics of Coronavirus Disease 2019 in China. Wei-jie Guan, Ph.D., Zheng-yi Ni, M.D. February 28, 2020. New England J. Med. DOI: 10.1056/NEJMoa2002032 
  1. Linking Air Pollution To Higher Coronavirus Death Rates. Amanda King. Harvard TH Chan School of Public Health. April 13, 2020 https://www.hsph.harvard.edu/biostatistics/2020/04/linking-air-pollution-to-higher-coronavirus-death-rates/ 
  1. Why Some COVID-19 Patients Crash: The Body's Immune System Might Be To Blame. April 7, 2020. Geoff Brumfiel NPR https://www.npr.org/sections/health-shots/2020/04/07/828091467/why-some-covid-19-patients-crash-the-bodys-immune-system-might-be-to-blame 
  1. New Rutgers Saliva Test for Coronavirus Gets FDA Approval. Rutgers University. Andrew Brooks. April 13, 2020 https://www.rutgers.edu/news/new-rutgers-saliva-test-coronavirus-gets-fda-approval
  1. Coronavirus saliva test gets FDA emergency use approval, Rutgers University says. Dan Mangan. CNBC. April 13, 2020 https://www.cnbc.com/2020/04/13/coronavirus-saliva-test-gets-fda-use-approval-rutgers-university-says.html 
  1. FDA Approves Phase III Clinical Trial of Tocilizumab for COVID-19 Pneumonia. Hannah Slater
  1. March 26, 2020 Cancer Network. https://www.cancernetwork.com/news/fda-approves-phase-iii-clinical-trial-tocilizumab-covid-19-pneumonia. 
  1. Genentech Announces FDA Approval of Clinical Trial for Actemra to Treat Hospitalized Patients With Severe COVID-19 Pneumonia. March 23, 2020. AP News Wire https://apnews.com/Business%20Wire/9e97b7ad899e4bb4bcc80b0d5fc72c7d
  1. Why COVID-19 hits smokers harder. By Nicoletta Lanese. Life Sciences. https://www.livescience.com/coronavirus-covid-19-risk-and-smoking.html 
  1. SARS‐CoV‐2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells. Soeren Lukassen et al, The EMBO Journal (April 17, 2020) e105114https://doi.org/10.15252/embj.20105114 
  1. Obesity Exacerbates the Cytokine Storm Elicited by Francisella tularensis Infection of Females and Is Associated with Increased Mortality. Mireya G. Ramos Muniz, Matthew Palfreeman et al. Advances in Emerging and Neglected Infectious Diseases June 26, 2018. BioMed Research International. https://www.hindawi.com/journals/bmri/2018/3412732/ 
  1. Angiotensin II Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors Usage is Associated with Improved Inflammatory Status and Clinical Outcomes in COVID-19 Patients With Hypertension 
  1. Guang Yang, Zihu Tan, Ling Zhou, Min Yang, Lang Peng, Jinjin Liu, Jingling Cai, Ru Yang, Junyan Han, Yafei Huang, Shaobin He, medRxiv April 4, 2020.03.31.20038935; doi: https://doi.org/10.1101/2020.03.31.20038935 
  1. University of British Columbia. "Trial drug can significantly block early stages of COVID-19 in engineered human tissues." ScienceDaily, 2 April 2020. www.sciencedaily.com/releases/2020/04/200402144526.htm. 
  1. Vanessa Monteil, Hyesoo Kwon, Patricia Prado, Astrid Hagelkrüys, Reiner A. Wimmer, Martin Stahl, Alexandra Leopoldi, Elena Garreta, Carmen Hurtado Del Pozo, Felipe Prosper, J.p. Romero, Gerald Wirnsberger, Haibo Zhang, Arthur S. Slutsky, Ryan Conder, Nuria Montserrat, Ali Mirazimi, Josef M. Penninger. Inhibition of SARS-CoV-2 infections in engineered human tissues using clinical-grade soluble human ACE2. Submitted to Cell, 2020 DOI: 10.1016/j.cell.2020.04.004 
  1. Decoy ACE2 receptors could be promising COVID-19 infection-preventing drug. April 3, 2020 Drug Target Review. https://www.drugtargetreview.com/news/59290/decoy-ace2-receptors-could-be-promising-covid-19-infection-preventing-drug/ 
  1. Gautret et al. (2020) Hydroxychloroquine and azithromycin as a treatment of COVID‐19: results of an open‐label non‐randomized clinical trial. International Journal of Antimicrobial Agents - In Press 17 March 2020 - DOI: 10.1016/j.ijantimicag.2020.105949
  1. French study finds anti-malarial and antibiotic combo could reduce COVID-19 duration. Darrell Etherington@etherington/March 19, 2020.
  1. Shen C, Wang Z, Zhao F, et al. Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma. JAMA. Published online March 27, 2020. doi:10.1001/jama.2020.4783 
  1. Roback JD, Guarner J. Convalescent Plasma to Treat COVID-19: Possibilities and Challenges. JAMA. Published online March 27, 2020. doi:10.1001/jama.2020.4940 
  1. Arturo Casadevall, Liise-anne Pirofski. The convalescent sera option for containing COVID-19. Published April 1, 2020; First published March 13, 2020. Citation Information: J Clin Invest. 2020;130(4):1545-1548. https://doi.org/10.1172/JCI138003. 
  1. Effectiveness of convalescent plasma therapy in severe COVID-19 patients Kai Duan, et al. Proceedings of the National Academy of Sciences Apr 6 2020, 202004168; DOI: 10.1073/pnas.2004168117 
  1. Pfizer PinPoints An Early Drug Candidate. Wall Street Journal. Jared S. Hopkins. April 10, 2020 
  1. On Developing New Drugs to Treat Covid-19. Binh Nᴳᴼ & Stephen Ditmore. Friday, April 10, 2020 Wall Street Journal. 
  1. Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D. Audio Interview: New Research on Possible Treatments for Covid-19. March 19, 2020. N Engl J Med 2020; 382:e30. DOI: 10.1056/NEJMe2005759 
  1. COVID-19 treatment might already exist. Nevan Krogan - Professor and Director of Quantitative Biosciences Institute, University of California, San Francisco. March 26, 2020. Live Science. 
  1. Anthony S. Fauci, M.D. et al. Covid-19 - Navigating the Uncharted. March 26, 2020 N Engl J Med 2020; 382:1268-1269 DOI: 10.1056/NEJMe2002387 
  1. Effect of low carbohydrate high fat diet on LDL cholesterol and gene expression in normal-weight, young adults: A randomized controlled study. Retterstøl, Kjetil et al. Atherosclerosis, October 17, 2018, Volume 279, 52-61.
  1. Spanish Ketogenic Mediterranean diet: a healthy cardiovascular diet for weight loss. Nutrition Journal, 2008, Volume 7, Number 1, Page 1. Joaquín Pérez-Guisado, Andrés Muñoz-Serrano, Ángeles Alonso-Moraga 
  1. Long-term successful weight loss with a combination biphasic ketogenic Mediterranean diet and Mediterranean diet maintenance protocol. Paoli, A., Bianco, A., Grimaldi, K. A., Lodi, A., & Bosco, G. (2013). Nutrients, 5 (12), 5205-17. doi:10.3390/nu5125205
  1. Effect of ketogenic Mediterranean diet with phytoextracts and low carbohydrates/high-protein meals on weight, cardiovascular risk factors, body composition and diet compliance in Italian council employees. Paoli, A., Cenci, L., & Grimaldi, K. A. (2011). Nutrition journal, 10, 112. doi:10.1186/1475-2891-10-112 
  1. Mediterranean Diet Reduces Risk of Incident Stroke in a Population With Varying Cardiovascular Disease Risk Profiles. Paterson, K. E., Myint, P. K., Jennings, A., Bain, L., Lentjes, M., Khaw, K. T., & Welch, A. A. (Oct 2018). Stroke, 49 (10), 2415-2420. Advance online publication. doi:10.1161/STROKEAHA.117.020258 
  1. Ahmad S, Moorthy MV, Demler OV, et al. Assessment of Risk Factors and Biomarkers Associated With Risk of Cardiovascular Disease Among Women Consuming a Mediterranean Diet. JAMA Netw Open. Dec. 7, 2018;1(8):e185708. doi:10.1001/jamanetworkopen.2018.5708
  1. Marialaura Bonaccio, Augusto Di Castelnuovo, Simona Costanzo, Mariarosaria Persichillo, Amalia De Curtis, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello. Interaction between Mediterranean diet and statins on mortality risk in patients with cardiovascular disease: Findings from the Moli-sani Study. International Journal of Cardiology, 2018; DOI: 10.1016/j.ijcard.2018.11.117
  1. Acute effects of three high-fat meals with different fat saturations on energy expenditure, substrate oxidation and satiety. Casas-Agustench, P. et al. Clinical Nutrition, Volume 28, Issue 1, 39-45 2009 
  1. The effect of dietary oleic, linoleic, and linolenic acids on fat oxidation and energy expenditure in healthy men. Jones, Peter J.H. et al. Metabolism: Clinical and Experimental, Volume 57, Issue 9, 1198-1203 
  1. The influence of the type of dietary fat on postprandial fat oxidation rates: monounsaturated (olive oil) vs. saturated fat (cream). LS Piers, KZ Walker, RM Stoney, MJ Soares and K O’Dea. International Journal of Obesity (2002) 26, 814-821 (2002) 
  1. Oleuropein, a Phenolic Compound in Extra Virgin Olive Oil, Increases Uncoupling Protein 1 Content in Brown Adipose Tissue and Enhances Noradrenaline and Adrenaline Secretions in Rats. Journal of Nutritional Science and Vitaminology, Released November 11, 2008. Yuriko Oi-Kano, Teruo Kawada, Tatsuo Watanabe, Fumihiro Koyama, Kenichi Watanabe, Reijirou Senbongi, Kazuo Iwai. 
  1. Effect of Distinct Lifestyle Interventions on Mobilization of Fat Storage Pools: The CENTRAL MRI Randomized Controlled Trial. Yftach Gepner, Ilan Shelef, Dan Schwarzfuchs, Hila Zelicha, Lilac Tene, Anat Yaskolka Meir, Gal Tsaban, Noa Cohen, Nitzan Bril, Michal Rein, Dana Serfaty, Shira Kenigsbuch, Oded Komy, Arik Wolak, Yoash Chassidim, Rachel Golan, Hilla Avni-Hassid, Avital Bilitzky, Benjamin Sarusi, Eyal Goshen, Elad Shemesh, Yaakov Henkin, Michael Stumvoll, Matthias Blüher, Joachim Thiery, Uta Ceglarek, Assaf Rudich, Meir J. Stampfer and Iris Shai. Circulation 2017;CIRCULATION AHA.117.030501, 2017.
  1. Weight Loss with a Low-Carbohydrate, Mediterranean, or Low-Fat Diet. Iris Shai, R.D., Ph.D., Dan Schwarzfuchs, M.D., Yaakov Henkin, M.D., Danit R. Shahar, R.D., Ph.D., Shula Witkow, R.D., M.P.H., Ilana Greenberg, R.D., M.P.H., Rachel Golan, R.D., M.P.H., Drora Fraser, Ph.D., Arkady Bolotin, Ph.D., Hilel Vardi, M.Sc., Osnat Tangi-Rozental, B.A., Rachel Zuk-Ramot, R.N., et al., for the Dietary Intervention Randomized Controlled Trial (DIRECT) Group. July 17, 2008. N Engl J Med 2008; 359:229-241
  1. Zong, G., Li, Y., Wanders, A.J., Alssema, M., Zock, P.L., Willett, W.C., Hu, F.B., Sun, Q. Intake of individual saturated fatty acids and risk of coronary heart disease in US men and women: two prospective longitudinal cohort studies BMJ. 2016;355:i5796.
  1. Mensink, R.P., Zock P.L., Kester, A.D., Katan, M.B. Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Am J Clin Nutr. 2003;77:1146-55. 
  1. Hu, F.B., J.E. Manson, Willett, W.C. Types of dietary fat and risk of coronary heart disease: a critical review. J Am Coll Nutr, 2001;20(1): p. 5-19. 
  1. Nut intake and 5-year changes in body weight and obesity risk in adults: results from the EPIC-PANACEA study. European Journal of Nutrition, 2017, Page 1 Heinz Freisling, Hwayoung Noh, Nadia Slimani.
  1. Acute effects of three high-fat meals with different fat saturations on energy expenditure, substrate oxidation and satiety. Casas-Agustench, P. et al. Clinical Nutrition, Volume 28, Issue 1, 39-45 2009 
  1. Fish oil intake induces UCP1 upregulation in brown and white adipose tissue via the sympathetic nervous system. Minji Kim, Tsuyoshi Goto, Rina Yu, Kunitoshi Uchida, Makoto Tominaga, Yuriko Kano, Nobuyuki Takahashi & Teruo Kawada. Scientific Reports volume 5, Article number: 18013 (2015) 
  1. Jens Lund, Lesli Hingstrup Larsen & Lotte Lauritzen (2018) Fish oil as a potential activator of brown and beige fat thermogenesis, Adipocyte, DOI: 10.1080/21623945.2018.1442980 
  1. Wiley. Fish consumption may prolong life. ScienceDaily, 18 July 2018. www.sciencedaily.com/releases/2018/07/180718082138.htm
  1. Zhang, P. Zhuang, W. He, J. N. Chen, W. Q. Wang, N. D. Freedman, C. C. Abnet, J. B. Wang, J. J. Jiao. Association of fish and long-chain omega-3 fatty acids intakes with total and cause-specific mortality: prospective analysis of 421 309 individuals. Journal of Internal Medicine, 2018; DOI: 10.1111/joim.12786 
  1. Dietary Fats and Cardiovascular Disease: A Presidential Advisory From the American Heart Association Frank M. Sacks, MD, FAHA, Chair, Alice H. Lichtenstein, DSc, FAHA, Jason H.Y. Wu, PhD, MSc, Lawrence J. Appel, MD, MPH, FAHA, Mark A. Creager, MD, FAHA, Penny M. Kris-Etherton, PhD, RD, FAHA, Michael Miller, MD, FAHA, Eric B. Rimm, ScD, FAHA, Lawrence L. Rudel, PhD, FAHA, Jennifer G. Robinson, MD, MPH, FAHA, Vice Chair, Neil J. Stone, MD, FAHA, and Linda V. Van Horn, PhD, RD, FAHA, Vice Chair On behalf of the American Heart Association.