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science nutrition blog

science nutrition <strong>blog</strong>

 By Steve Blechman


Recently, a review study and meta-analysis was published in the May-June 2023 issue of the Journal of the American Nutrition Association on the potential muscle performance benefits of nitrate (N03) booster supplementation in quick, short, high-intensity explosive exercise such as sprinting and weightlifting.

Nineteen (19) human studies met the inclusion criteria in this meta-analysis. “The studies included in the systemic review were high quality with many scoring 10/10. All studies were placebo-controlled, randomized crossover experiments with low selection/detection bias, double-blinded and with low performance bias.” Randomized studies are considered the gold standard. Randomization is important for establishing cause and effect.

Nitrate (NO3) booster research is building and “the findings from this meta-analysis highlights the potential positive ergogenic effect of dietary and NO3 supplementation” on skeletal muscle contractility, peak power output (PPO), mean power outputs (MPO) in healthy humans. The researchers acknowledge “our findings support and extends to the findings of previous systemic reviews and meta-analysis that have reported that an NO3 supplementation (or nitrate oxide supplements) can enhance muscle power and performance in healthy adults and trained individuals.”

Another recent meta-analysis study and review was published May 31, 2023, in the Journal Antioxidants. It reported that dietary nitrate (NO3) supplementation improved performance outcomes during single and repeated bouts of short duration, high-intensity exercise. “The systemic review and meta-analysis included 27 and 23 studies respectfully.” The researchers concluded that “athletes competing in sports requiring single or repeated bouts of high intensity exercise may benefit from NO3 supplementation.”

“Nitric oxide stimulating dietary supplements are widely available and marketed to strength athletes and weightlifters seeking to increase muscle performance and augment training adaptations. These supplements contain ingredients classified as nitric oxide (NO) precursor (i.e., “NO boosters”).” (Nutrients, January 28, 2023)

The most popular NO precursors include the amino acid L-citrulline or citrulline malate, which provides one of the body’s two nitric oxide pathways (citrulline arginine pathway). The other pathway is the nitrate-nitrite pathway. Both pathways boost nitric oxide, which may enhance exercise performance.

“Nitrates (NO3) have become increasingly popular for their potential role as an ergogenic aid” and improving human performance.

A review of the scientific literature has shown that nitrate taken acutely or chronically in the range up 300 to 1,041 milligrams two to three hours before exercise is an effective ergogenic aid. (Nutrients, September 13, 2021)

Research has shown that for muscle strength gains, a minimum acute dose of 400 milligrams of nitrate (NO3) provides the best results. (Journal of Strength and Conditioning Research, December 1, 2022)


Introducing Advanced Molecular Labs (AML) NITRATE NO3 BOOSTER, a high-performance, scientifically advanced, super nitrate (NO3) formula. It contains patented citrulline nitrate (NO3T®), a patented nitric oxide (NO) booster that promotes nitric oxide by two pathways (L-citrulline and nitrate) in a single ingredient.†

Citrulline nitrate is a unique nitric oxide-boosting compound containing the amino acid L-citrulline, specifically bonded to nitrate. Nitrate is naturally found in red beets, spinach, kale, and arugula and is converted to nitric oxide in the body. Citrulline is found in a number of foods such as watermelon, and as a dietary supplement is superior to L-arginine for increasing blood levels of arginine. Therefore, L-citrulline is more effective than L-arginine for boosting nitric oxide production.†

Arginine is a precursor, which the body uses to generate nitric oxide – an important signaling molecule that may improve muscular function and exercise performance. Nitric oxide (NO) enhances vasodilation (widening of blood vessels), which may favorably impact greater blood flow, oxygen and nutrient delivery to working muscles.†

Greater nitric oxide (NO) production supports better muscle pumps! Nitric oxide (NO) may also enhance energy production, work capacity, time to exhaustion and increasing the number of repetitions performed in the gym during training.†

AML NITRATE NO3 BOOSTER capsules contain 2000mg of citrulline nitrate per dose (standardized for 27% nitrate providing 540mg nitrate).

AML NITRATE NO3 BOOSTER also contains a science-based, synergistic blend of nitric oxide-boosting vitamins, antioxidants and polyphenols: Folic Acid, Vitamin B-12, Vitamin C, Pine Bark Extract (standardized for 95% Proanthocyanidins), and Grape Skin Extract (standardized for 30% polyphenols), to help maximize and support nitric oxide (NO) production and bioavailability.†

For Best results, AML NITRATE NO3 BOOSTER capsules can be taken 1-1½ hours before exercise with AML PREWORKOUT or AML PREWORKOUT X-TREME.

AML NITRATE NO3 BOOSTER capsules can also be taken 1-1½ hours before bedtime with AML SEX COCKTAIL for better sexual performance in the bedroom.

If preferred, capsules can be opened and added to AML Preworkout or AML Sex Cocktail.


† These statements have not been evaluated by the U.S. Food and Drug administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


© Published by Advanced Research Media, Inc. 2023

© Reprinted with permission from Advanced Research Media, Inc.



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