science nutrition blog

By Robert Schinetsky

Fat burners are among the most popular dietary supplements lining store shelves. With approximately 70% of the population either overweight or obese and 40% dieting at any given time, it's no wonder that top thermogenic fat burners and effective thermogenic fat burners are in high demand.

Unfortunately, many fat burners on the market do not live up to their claims. Most are glorified stim bombs that leave users feeling overstimulated, jittery, and anxious without effectively burning body fat or boosting metabolism.

However, not all hope is lost. By understanding which ingredients are scientifically backed, you can find the most effective thermogenic fat burner to support your weight management goals. Ahead, we will discuss the best thermogenic for energy and weight loss, including brown fat-activating compounds.

But first, let's briefly review the two main types of adipose tissue in the body: white fat and brown fat.

A Brief Primer on Brown Adipose Tissue (Brown Fat)

Researchers have long known that the human body contains two specific, yet very different types of fat cells[1]:

- White fat - a relatively inert form of stored energy composed of a single, large fat droplet.

- Brown fat - cells composed of many small droplets loaded with mitochondria. Brown fat is more metabolically active, burns calories at a higher rate than white fat, and helps maintain core temperature when exposed to cold weather.

Increasing brown fat activity or converting white fat to brown fat can lead to greater calorie conversion into heat, reducing body fat and weight. However, brown fat activity tends to decline with age, complicating weight management.

Now, let's explore the top rated thermogenic supplements and the best weight loss thermogenic options to stimulate brown adipose tissue and enhance metabolic rate.

Top 10 Thermogenic & Fat Burning Supplements

Choosing the best thermogenic fat burner for men and women can be overwhelming, but knowing the most effective options can make all the difference in your weight management journey. Here, we explore the top thermogenic fat burners that have shown promise in scientific research:

Caffeine

A powerful central nervous stimulant that increases energy, alertness, and metabolism. Consuming caffeine can boost thermogenesis and increase energy expenditure.

p-Synephrine

Found in Citrus Aurantium, it boosts metabolism and fat loss by stimulating beta-3 adrenergic receptors in brown fat.

Forskolin

Derived from coleus forskohlii, it activates enzymes in brown fat to promote thermogenesis without being a stimulant.

Dopamine Activators

Compounds like L-Tyrosine and L-Dopa increase dopamine production, enhancing energy expenditure.

Pungent Spices (Capsaicin, Piperine, Ginger (Gingerols), Cinnamon)

Spices like capsaicin, piperine, ginger, and cinnamon boost metabolism and enhance fat loss.

Ursolic Acid

Found in apple peels, it may increase brown fat and muscle mass.

Olive Leaf Extract

Contains oleuropein, which enhances fat burning and supports thyroid function.

Kaempferol

A polyphenol that stimulates thermogenesis in muscle cells and brown fat.

Melatonin

Known for regulating sleep, it also plays a role in energy metabolism.

These top thermogenic fat burners are designed to support overall weight loss goals by enhancing metabolic rate and stimulating brown adipose tissue.

© Published by Advanced Research Media, Inc., 2023

© Reprinted with permission from Advanced Research Media, Inc.

References:

1. Seale P, Lazar MA. Brown fat in humans: turning up the heat on obesity. Diabetes. 2009;58(7):1482-4.
2. Goldstein ER, Ziegenfuss T, Kalman D, et al. International society of sports nutrition position stand: caffeine and performance. J Int Soc Sports Nutr. 2010;7(1):5. Published 2010 Jan 27. doi:10.1186/1550-2783-7-5
3. Dulloo AG, Geissler CA, et al. Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers. Am J Clin Nutr 1989;49, 44-50.
4. Yoneshiro, Takeshi, et al. Tea catechin and caffeine activate brown adipose tissue and increase cold-induced thermogenic capacity in humans. The American Journal of Clinical Nutrition, vol. 105, no. 4, 2017, pp. 873-881.
5. Astrup A, Toubro S, Cannon S. Caffeine: A double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers. Am J Clin Nutr. 1990;51:759-67.
6. Stohs SJ, Preuss HG, et al. Effects of p-synephrine alone and in combination with selected bioflavonoids on resting metabolism, blood pressure, heart rate and self-reported mood changes. Int J Med Sci 2015;8, 295-301.
7. Molinoff, Perry B. Alpha- and beta-Adrenergic Receptor Subtypes Properties, Distribution and Regulation. Drugs, vol. 28, no. Supplement 2, 1984, pp. 1-15.
8. Stohs SJ, Preuss HG, Shara M. A review of the receptor-binding properties of p-synephrine as related to its pharmacological effects. Oxid Med Cell Longev. 2011;2011:1-9. doi: 10.1155/2011/482973.
9. Ratamess NA, Bush JA, Kang J, et al. The effects of supplementation with P-Synephrine alone and in combination with caffeine on resistance exercise performance. Journal of the International Society of Sports Nutrition. 2015;12:35. doi:10.1186/s12970-015-0096-5.
10. Ratamess NA, Bush JA, Kang J, et al. The Effects of Supplementation with p-Synephrine Alone and in Combination with Caffeine on Metabolic, Lipolytic, and Cardiovascular Responses during Resistance Exercise. J Am Coll Nutr. 2016;35(8):657-669. doi:10.1080/07315724.2016.1150223.
11. Zhao J, Cannon B and Nedergaard J. alpha1-Adrenergic stimulation potentiates the thermogenic action of beta3-adrenoreceptor-generated cAMP in brown fat cells. J Biol Chem 1997;272, 32847-32856.
12. Scarpace PJ and Matheny M. Thermogenesis in brown adipose tissue with age: post-receptor activation by forskolin. Pflugers Arch 1996;431, 388-394.
13. Arias-Carrion, O., & Poppel, E. (2007). Dopamine, learning, and reward-seeking behavior. Acta Neurobiologiae Experimentalis, 67(4), 481-488.
14. Treadway MT, Buckholtz JW, Cowan RL, et al. Dopaminergic Mechanisms of Individual Differences in Human Effort-Based Decision-Making. J Neurosci. 2012;32(18):6170 LP-6176.
15. Hull KM and Maher TJ. Effects of L-tyrosine on mixed-acting sympathomimetic-induced pressor actions. Pharmacol Biochem Behav 1992;43, 1047-1052.
16. Tharakan B, Dhanasekaran M, et al. Anti-Parkinson botanical Mucuna pruriens prevents levodopa induced plasmid and genomic DNA damage. Phytother Res 2007;21, 1124-1126.
17. Katzenschlager R, Evans A, et al. Mucuna pruriens in Parkinson's disease: a double blind clinical and pharmacological study. J Neurol Neurosurg Psychiatry 2004;75, 1672-1677.
18. Ruttimann Y, Schutz Y, et al. Thermogenic and metabolic effects of dopamine in healthy men. Crit Care Med 1991;19, 1030-1036.
19. Yoneshiro T, Aita S, et al. Nonpungent capsaicin analogs (capsinoids) increase energy expenditure through the activation of brown adipose tissue in humans. Am J Clin Nutr 2012;95, 845-850.
20. Saito M and Yoneshiro T. Capsinoids and related food ingredients activating brown fat thermogenesis and reducing body fat in humans. Curr Opin Lipidol 2013;24, 71-77.
21. Yoneshiro T, Aita S, et al. Recruited brown adipose tissue as an antiobesity agent in humans. J Clin Invest 2013;123, 3404-3408.
22. Yoneshiro T and Saito M. Transient receptor potential activated brown fat thermogenesis as a target of food ingredients for obesity management. Curr Opin Clin Nutr Metab Care 2013;16, 625-631.
23. McNamara FN, Randall A and Gunthorpe MJ. Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1). Br J Pharmacol 2005;144, 781-790.
24. Godard, Michael P., et al. Body Composition and Hormonal Adaptations Associated with Forskolin Consumption in Overweight and Obese Men. Obesity Research, vol. 13, no. 8, 2005, pp. 1335-1343.
25. Jagtap M, Chandola HM, Ravishankar B. Clinical efficacy of Coleus forskohlii (Willd.) Briq. (Makandi) in hypertension of geriatric population. Ayu. 2011;32(1):59-65.
26. Kunkel SD, Elmore CJ, et al. Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease. PLoS One 2012;7, e39332
27. Jia, Yaoyao, et al. Ursolic acid improves lipid and glucose metabolism in high-fat-fed C57BL/6J mice by activating peroxisome proliferator-activated receptor alpha and hepatic autophagy. Molecular Nutrition & Food Research, vol. 59, no. 2, 2014, pp. 344-354.
28. Chu, Xia, et al. Ursolic acid increases energy expenditure through enhancing free fatty acid uptake and β-oxidation via an UCP3/AMPK-dependent pathway in skeletal muscle. Molecular Nutrition & Food Research, vol. 59, no. 8, 2015, pp. 1491-1503.
29. Kunkel SD, et al. mRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle mass. Cell Metab. (2011)
30. da-Silva WS, Harney JW, et al. The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation. Diabetes 2007;56, 767-776.
31. Busiello RA, Savarese S, Lombardi A. Mitochondrial uncoupling proteins and energy metabolism. Front Physiol. 2015;6:36. Published 2015 Feb 10. doi:10.3389/fphys.2015.00036
32. Oi-Kano, Yuriko, et al. Oleuropein aglycone enhances UCP1 expression in brown adipose tissue in high-fat-diet-induced obese rats by activating β-adrenergic signaling. The Journal of Nutritional Biochemistry, vol. 40, 2017, pp. 209-218.
33. Al-Qarawi, A. A., Al-Damegh, M. A. and ElMougy, S. A. (2002), Effect of freeze dried extract of Olea europaea on the pituitary-thyroid axis in rats. Phytother. Res., 16: 286-287. doi:10.1002/ptr.855.
34. Periasamy M, Herrera JL, Reis FCG. Skeletal Muscle Thermogenesis and Its Role in Whole Body Energy Metabolism. Diabetes Metab J. 2017;41(5):327-336.
35. Wolden-Hanson T, Mitton DR, et al. Daily melatonin administration to middle-aged male rats suppresses body weight, intraabdominal adiposity, and plasma leptin and insulin independent of food intake and total body fat. Endocrinology 2000;141, 487-497.
36. Tan DX, Manchester LC, et al. Significance and application of melatonin in the regulation of brown adipose tissue metabolism: relation to human obesity. Obes Rev 2011;12, 167-188.
37. Amstrup, Anne K., et al. Reduced fat mass and increased lean mass in response to 1 year of melatonin treatment in postmenopausal women: A randomized placebo-controlled trial. Clinical Endocrinology, vol. 84, no. 3, 2015, pp. 342-347.
38. Watanabe M, Houten SM, et al. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 2006;439, 484-489.
39. Broeders, Evie P.M., et al. The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity. Cell Metabolism, vol. 22, no. 3, 2015, pp. 418-426.
40. Mullur R, Liu YY, Brent GA. Thyroid hormone regulation of metabolism. Physiol Rev. 2014;94(2):355-82.
41. Holtzer P (2002): Sensory neurone responses to mucosal noxae in the upper gut: relevance to mucosal integrity and gastrointestinal pain. Mot. 14, 459-475.
42. Ward SM, Bayguinov J, Won K-J, Gryndy D & Berthoud HR (2003): Distribution of vanilloid receptor (VR1) in the gastrointestinal tract. J. Comp. Neurol. 465, 121-135.
43. Belza, A., and A. B. Jessen. Bioactive food stimulants of sympathetic activity: effect on 24-h energy expenditure and fat oxidation. European Journal of Clinical Nutrition, vol. 59, no. 6, 2005, pp. 733-741.
44. Reinbach, H.C., et al. Effects of capsaicin, green tea and CH-19 sweet pepper on appetite and energy intake in humans in negative and positive energy balance. Clinical Nutrition, vol. 28, no. 3, 2009, pp. 260-265.
45. Ludy MJ, Moore GE, Mattes RD. The effects of capsaicin and capsiate on energy balance: critical review and meta-analyses of studies in humans. Chem Senses. 2011;37(2):103-21.