Getting lean and keeping it off requires a comprehensive approach that increases energy expenditure by burning body fat while managing appetite to maintain the loss of unwanted fat. Recent scientific evidence has shown that a process known as thermogenesis increases energy expenditure while burning body fat in humans1-3 by stimulating the activity of brown adipose tissue (BAT). Brown adipose tissue is a unique type of fat cell that can effectively uncouple the normally linked process of fat burning with cellular energy (ATP) production within the mitochondria. As a result, instead of the energy from fat being used to synthesize ATP, it is instead converted into heat, increasing energy expenditure. BAT’s ability to burn fat and increase energy expenditure presents a promising target for fat loss.

Several months ago, Steve Blechman and Advanced Molecular Labs (AML) launched the revolutionary fat-torching product Thermo Heat that has an exclusive blend of compounds that attack body fat by activating thermogenic fat loss and energy expenditure, while also activating your body’s own appetite-suppressing hormones and neurotransmitters in order to mitigate food consumption for smoother dieting and sustained fat loss.
Thermo Heat has a combination of ingredients designed to enhance energy and mental focus to support intense training, yet without too much stimulation. Tyrosine is one of the stimulatory compounds in Thermo Heat that triggers the production of the excitatory neurotransmitter dopamine, which regulates neurons triggering thermogenesis and appetite control while also having an arousing effect that increases alertness. In addition, Thermo Heat contains the well-known stimulant caffeine, which also heightens alertness.
Realizing the stimulatory nature of these compounds is fantastic for fat loss and exercise performance, they most likely interfere with the all-important sleep— which is extremely important for complete recuperation that drives muscle growth and reduces weight gain. So, with that in mind, Steve Blechman and AML designed the perfect complement to Thermo Heat that when consumed before an evening meal or at bedtime, maintains an elevated level of thermogenic fat burning throughout the night while, at the same time, reducing stress and promoting sleep. This new product, Thermo Heat Nighttime, accomplishes this, in part, by replacing the aforementioned stimulatory molecules tyrosine, caffeine, synephrine and thyroid hormone activators with several compounds that strongly induce a relaxed state that potently induces sleep— while also possessing compounds that burn fat and suppress appetite.

Capsaicinoids Found in Thermo Heat Nighttime Thermogenically Torch Fat

BAT thermogenesis is typically activated by stimulating a receptor molecule in the brain belonging to the transient receptor potential vanilloid (TRPV) family, whose normal function is to regulate body temperature. Activation of TRPV within the brain triggers the sympathetic nervous system resulting in noradrenaline release, which subsequently enhances fatty acid oxidation. Several studies have shown that additional members of the TRPV receptor family are activated outside of the brain by various food-related compounds that bind to TRPV receptors within the oral cavity or gastrointestinal tract, yet still activate the sympathetic nervous system and BAT-activated thermogenesis. Among the TRPV activators investigated so far, the most extensively studied have been capsaicin and other capsaicin-like compounds known as capsaicinoids that are abundantly found in Thermo Heat Nighttime. Capsaicinoids naturally occur in chili peppers, where they contribute to the hot and spicy flavor of the chili pepper.
In these studies, capsaicinoids were shown to increase BAT thermogenesis in humans through the activation of a specific member of the TRPV family, TRPV1, found in the oral cavity and gastrointestinal tract. Activation of TRPV1 stimulates the sympathetic nervous system, which releases noradrenaline, driving BAT thermogenesis and fat loss.4-6 In addition, other studies showed that longer term ingestion of roughly six weeks increased BAT-dependent thermogenesis, which reduced body fat.7-8

Capsaicinoids Reduce Hunger

Interventions aimed to improve weight loss and weight maintenance have rapidly embraced the use of several naturally occurring compounds that burn fat while also decreasing appetite. Capsaicinoids have been shown to reduce food intake9-11 while also significantly reducing the desire to eat more food.10
Although an influence on appetite has been observed in several trials, the mechanism of action is not fully understood. It may be that the release of noradrenaline triggered by capsaicin, as previously mentioned, minimizes appetite as the stimulation of the noradrenaline receptors in the brain has been shown to produce feelings of satiety.12 In addition, the consumption of capsaicin has also been shown to cause an increase in gut-derived hormone GLP-1, which regulates regions of the brain that regulate food intake, resulting in reduced hunger.13
All told, capsaicinoids, which are abundantly found in Thermo Heat Nighttime, potently stimulate and preserve fat loss as recent evidence clearly shows their comprehensive ability to increase energy expenditure and fat oxidation while also reducing appetite.

Thermo Heat Nighttime Promotes Relaxation and Sleep

Though not readily appreciated, sleep is an extremely potent performance enhancer that stimulates the release of anabolic hormones14 such as testosterone and growth hormone, triggering anabolic processes within the musculoskeletal system. In addition, studies have also shown that ample sleep is necessary to control bodyweight.15
In order to take advantage of the fat-fighting, muscle-building processes stimulated during sleep, Thermo Heat Nighttime potently induces relaxation and sleepiness. Melatonin, which is found abundantly in Thermo Heat Nighttime, is a hormone secreted by the pineal gland in the brain that regulates the sleep/wake cycle helping you fall asleep. Melatonin is also involved in energy metabolism and bodyweight control. Many studies show that melatonin reduces bodyweight and abdominal fat16 without eating less or increasing physical activity. Conceivably, melatonin reduces fat without decreasing food consumption or physical activity by activating BAT-driven thermogenesis17, which autonomously increases energy expenditure and thus fat loss.
In addition to the powerful sleep-enhancing effects of melatonin, compounds in Thermo Heat Nighttime also encourage sleep by strongly reducing stress and anxiety. One of those compounds being L-theanine, an amino acid naturally found in tea that is able to cross the blood-brain barrier and influence activity of the central nervous system.18 Studies have shown the ability of L-theanine to affect the central nervous system results in increased relaxation and lowered anxiety along with improved sleep quality.19-20
In addition to L-theanine, Thermo Heat Nighttime also contains 5-hydroxytryptophan (5-HTP), which is an amino acid that can also pass the blood-brain barrier where it is converted into the neurotransmitter serotonin. The increased production of serotonin is associated with feelings of tiredness and fatigue, as serotonin regulates the sleep-wake cycle. In addition, serotonin curbs cravings and reduces appetite, ultimately resulting in weight loss. As a result, 5-HTP promotes sleepiness while curbing appetite by increasing serotonin production.

Stress Reduction With GABA

Gamma-aminobutyric acid (GABA) is one of the chief inhibitory neurotransmitters in humans.21 The inhibitory effect of GABA on the body results in a considerable reduction in stress and anxiety22, making it an integral part of the relaxing influence of Thermo Heat Nighttime. In addition, GABA has also been shown to have peripheral activity in various tissues and organs throughout the body regulating cardiovascular functions, renal functions and regulation of the pituitary gland. Interestingly, GABA’s regulation of the pituitary triggers the release of growth hormone23, promoting an anabolic environment that supports greater muscle growth while also promoting fat loss.

Unique Spice Blend That Subdues Appetite and Incinerates Fat

Thermo Heat Nighttime contains a unique blend of spices that suppress appetite, including piperine, the spicy compound from black pepper; cinnamaldehyde, the pungent ingredient in cinnamon; and gingerol, the active constituent in ginger. Piperine and gingerol have been reported to activate the TRPV1 receptor while cinnamaldehyde activates the TRPA1 receptor, a member within the TRPV1 family of receptors. Activation of this family of receptors triggers thermogenic energy expenditure in a similar fashion to capsaicinoids24-25, which ultimately depletes body fat. In addition, all three compounds have been shown to decrease appetite, putting them in a similar category with capsaicin and capsaicinoids as compounds that effectively trigger long-term fat loss by increasing energy expenditure while also decreasing appetite.26-28 Importantly, the spice known as grains of paradise has also been shown to trigger thermogenesis in a similar fashion to the three aforementioned spices found in Thermo Heat Nighttime.29 Yet importantly, there is very convincing evidence also showing that grains of paradise is likely toxic to the liver30, while there is absolutely no evidence whatsoever linking piperine, gingerol or cinnamaldehyde with toxicity.

For most of Michael Rudolph’s career he has been engrossed in the exercise world as either an athlete (he played college football at Hofstra University), personal trainer or as a Research Scientist (he earned a B.Sc. in Exercise Science at Hofstra University and a Ph.D. in Biochemistry and Molecular Biology from Stony Brook University). After earning his Ph.D., Michael investigated the molecular biology of exercise as a fellow at Harvard Medical School and Columbia University for over eight years. That research contributed seminally to understanding the function of the incredibly important cellular energy sensor AMPK— leading to numerous publications in peer-reviewed journals including the journal Nature. Michael is currently a scientist working at the New York Structural Biology Center doing contract work for the Department of Defense on a project involving national security.

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