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science nutrition blog

science nutrition <strong>blog</strong>

By Steve Blechman


More than 25 years ago as head of product development for Twinlab over a 27-year period, I developed and formulated the original Twinlab Ripped Fuel. It was the first ephedra/caffeine combination product in the United States and one of the best-selling fat-loss dietary supplement products of all time.

In 1999 I was awarded a United States patent as the inventor of the first citrus aurantium extract/caffeine combination product for enhancing weight loss and preserving lean body mass.

Over the past seven years I developed THERMO HEAT® – the most scientifically advanced thermogenic brown fat-activating fat burning supplement line ever developed! The science and cornerstone of the product line was research based on brown adipose tissue (BAT) known as brown fat!

For the past 5 years, I have written many articles on the health and fat-loss benefits of brown adipose tissue (brown fat). The widely held belief that all body fat is bad is currently being heavily scrutinized, due to the recent discovery of a different type of fat in humans known as brown fat. This type of body fat can actually burn off energy in the form of heat by a process known as thermogenesis, which can ultimately reduce overall body fat. 

The body has two forms of fat: white fat, or unwanted fat that can lie directly underneath the skin, and brown fat, which often is found in the shoulder blade region or the neck. Unlike white fat, brown fat is the good fat as it can help burn more calories. The more brown fat you have, the more calories you burn.

Brown fat is packed with mitochondria loaded with UCP-1, the protein that uncouples fat burning with ATP (energy) production instead of converting the energy into heat via thermogenesis, making the mitochondria effectively the furnace of the cell. The emergence of brown fat as a readily available fat-burning furnace is revolutionary, but like any fire, it requires the proper kindling materials. The ability to get lean by producing extra brown fat, or enhancing the activity of existing brown fat, represents a promising way to burn fat and lose weight.

Several landmark discoveries and approaches to enhancing brown fat function are being explored at major research centers and universities worldwide, with great excitement. Brown fat research is a hot topic today.

In 2021 it was time for me to develop the newest revolutionary brown fat-activating thermogenic fat loss supplement – based on the latest cutting-edge science, and containing the latest research-based thermogenic and brown fat-activating fat burners! For complete scientific review of AML™ THERMO HEAT® COCKTAIL™ see the March 11, 2021 article entitled: “New Revolutionary Cocktail for Fat Loss!” by Robert Schinetsky.

The article says, “AML™ THERMO HEAT® COCKTAIL™ is a great dopamine activator that can improve exercise performance, enhance calorie burning and support weight loss as part of a low-calorie diet and exercise program. It can be used as a pre-workout or productivity supplement, but really shines when taken before fasted cardio, as this is the main driver behind its formulation. For added weight-loss support and lean mass retention during dieting, AML suggests stacking AML™ THERMO HEAT® COCKTAIL™ with THERMO HEAT® Fat Burning Protein. AML™ THERMO HEAT® COCKTAIL™ would be consumed pre-workout and then immediately follow your training with a serving of THERMO® HEAT Fat Burning Protein.”

AML™ THERMO HEAT® is most scientifically advanced brown fat and thermogenic supplement line ever developed! One of those products, AML™ THERMO HEAT® FAT BURNING PROTEIN, contains nutrients that have been shown to increase brown fat activation and thermogenesis, including whey protein enriched with 5 grams of the branched-chain amino acid leucine. Leucine is the key anabolic trigger of protein synthesis. Supplemental leucine by itself and synergistically combined with vitamin D3 and medium-chain-triglycerides (MCTs) can help prevent lean muscle loss, especially during low-calorie, low-carb or ketogenic diets. Also, two double-blind human studies have shown that the amino acid leucine (2.4 grams daily) and citrulline (2 grams daily) can lower the inflammatory cytokine interleukin-6 (IL-6), and c-reactive protein, a marker of inflammation in the body. (SL Nutrition and Metabolism, September 5, 2017). (BMC Research Notes, February 15, 2019).

AML™ THERMO HEAT® FAT BURNING PROTEIN also contains nitric oxide activators that have been shown to activate BAT and thermogenesis. Nitric oxide and nitric oxide precursors such as citrulline have been shown to increase BAT and thermogenesis. Grapeskin extract has been shown to increase nitric oxide production. Polyphenols are being studied for their role in fat metabolism and obesity management. Folic acid also boosts nitric oxide availability, by increasing BH4 and decreasing homocysteine levels. Research has shown that folic acid can lower homocysteine levels, increase insulin sensitivity and lower fasting insulin levels in type 2 diabetes. Medium-chain triglycerides (MCTs), grains of paradise (40mg - standardized for 12% paradol, a clinically effective dose) and BioPerine® black pepper fruit extract are all included for further activation of brown adipose tissue (BAT) and thermogenesis. Grains of paradise, a spice containing 6-paradol, like chili peppers containing capsaicin, activate BAT, increase whole-body energy expenditure and decrease visceral fat (deep abdominal fat) in humans. It also contains allulose, a natural, low-calorie, fat-burning, thermogenic sweetener. It is approved for low-sugar/low-carb or ketogenic diets. Allulose does not impact blood sugar or insulin levels.

As part of a calorie-restricted diet and exercise (aerobic and resistance training) program, AML™ THERMO HEAT® COCKTAIL™ taken pre-workout (preferably before fasted cardio), and THERMO HEAT® Fat-Burning Protein taken post-workout, can help enhance fat loss and preserve lean body mass when following a low-calorie, low-carbohydrate or ketogenic diet. A healthy weight loss is one that enhances the reduction of body fat and preserves lean body mass while dieting.†


†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.




  1. New Revolutionary Cocktail for Fat Loss by Robert Schinetsky. March 11, 2021.


  1. AML™ THERMO HEAT® FAT BURNING PROTEIN: NEW Revolutionary & Advanced Scientific Formula! April 8, 2019.


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  1. The Thermo Heat® Weight Loss Revolution, by Michael J. Rudolph, Ph.D, including the foreword by Daniel L. Friedman, MD and Eugene B Friedman, MD.


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