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science nutrition blog

science nutrition <strong>blog</strong>

 By Steve Blechman

 

Multivitamin Adverse Effects on Mental Health

A new study published May 24th, 2023 in the American Journal of Clinical Nutrition reported, “Daily multivitamin supplementation compared with placebo, improves memory in older adults.” The researchers said, “Multivitamin supplementation holds promise as a safe and accessible approach to maintaining cognitive health in older age.”

The study also reported, “Few effective strategies have been shown in randomized clinical trials to improve memory or slow cognitive decline among older adults. Nutrition interventions may play an important role because the brain requires several nutrients for optimal health, and deficiencies in one or more of these nutrients may accelerate cognitive decline.”

This newly published clinical trial, “included more than 3,500 participants aged 60 and older.” “Compared to the placebo group, participants randomized to multivitamin supplementation did significantly better on the memory test at the pre-specified primary time point of one year, with benefits sustained across three years of follow-up.” The authors of the study said, “Multivitamin supplementation has cognitive benefits, but further research will be necessary to identify the specific nutrients contributing the most to this benefit and the underlying mechanisms involved.”

Not all multivitamin nutrients are good for mental health! New research says that too much iron, copper and manganese boost oxidative damage and neural inflammation in the brain. High body iron, manganese and copper has also been associated with the increased risk of cardiovascular disease and cancer.

Research has shown that accumulation of iron, copper and manganese in the brain and central nervous system promotes neurotoxicity and neurologic degenerative diseases such as Alzheimer's and Parkinson's disease.

Because of the potential health risks associated with the high iron, copper and manganese intake, Advanced Molecular Labs (AML) THERMO HEAT™ MULTI does not contain any of these mineral elements.

© Published by Advanced Research Media, Inc. 2023

© Reprinted with permission from Advanced Research Media, Inc. 2023

References:

1. Multivitamin supplementation improves memory in older adults: a randomized clinical trial. Lok-Kin Yeung, Daniel M. Alschuler, Melanie Wall, Heike Luttmann-Gibson, Trisha Copeland, Christiane Hale, Richard P. Sloan, Howard D. Sesso, JoAnn E. Manson, Adam M. Brickman. The American Journal of Clinical Nutrition. May 24, 2023

2. Study finds daily multivitamin supplements improve memory and slow cognitive aging in older adults. Brigham and Women's Hospital. May 24, 2023. MedicalXpress.com https://medicalxpress.com/news/2023-05-daily-multivitamin-supplements-memory-cognitive.html

3. Martínez-Hernández MI, Acosta-Saavedra LC, Hernández-Kelly LC, Loaeza-Loaeza J, Ortega A. Microglial Activation in Metal Neurotoxicity: Impact in Neurodegenerative Diseases. Biomed Res Int. 2023 Jan 31;2023:7389508. doi: 10.1155/2023/7389508. PMID: 36760476; PMCID: PMC9904912.

4. Maynard CJ, Cappai R, Volitakis I, Cherny RA, White AR, Beyreuther K, Masters CL, Bush AI, Li QX. Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron. J Biol Chem. 2002 Nov 22;277(47):44670-6. doi: 10.1074/jbc.M204379200. Epub 2002 Sep 4. PMID: 12215434.

5. Hernández RB, Carrascal M, Abian J, Michalke B, Farina M, Gonzalez YR, Iyirhiaro GO, Moteshareie H, Burnside D, Golshani A, Suñol C. Manganese-induced neurotoxicity in cerebellar granule neurons due to perturbation of cell network pathways with potential implications for neurodegenerative disorders. Metallomics. 2020 Nov 1;12(11):1656-1678. doi: 10.1039/d0mt00085j. Epub 2020 Sep 7. PMID: 33206086.

6. Huat TJ, Camats-Perna J, Newcombe EA, Valmas N, Kitazawa M, Medeiros R. Metal Toxicity Links to Alzheimer's Disease and Neuroinflammation. J Mol Biol. 2019 Apr 19;431(9):1843-1868. doi: 10.1016/j.jmb.2019.01.018. Epub 2019 Jan 18. PMID: 30664867; PMCID: PMC6475603.

7. Yokel RA. Blood-brain barrier flux of aluminum, manganese, iron and other metals suspected to contribute to metal-induced neurodegeneration. J Alzheimers Dis. 2006 Nov;10(2-3):223-53. doi: 10.3233/jad-2006-102-309. PMID: 17119290.

8. Yokel RA. Blood-brain barrier flux of aluminum, manganese, iron and other metals suspected to contribute to metal-induced neurodegeneration. J Alzheimers Dis. 2006 Nov;10(2-3):223-53. doi: 10.3233/jad-2006-102-309. PMID: 17119290.

9. Budinger D, Barral S, Soo AKS, Kurian MA. The role of manganese dysregulation in neurological disease: emerging evidence. Lancet Neurol. 2021 Nov;20(11):956-968. doi: 10.1016/S1474-4422(21)00238-6. PMID: 34687639.

10. Budinger D, Barral S, Soo AKS, Kurian MA. The role of manganese dysregulation in neurological disease: emerging evidence. Lancet Neurol. 2021 Nov;20(11):956-968. doi: 10.1016/S1474-4422(21)00238-6. PMID: 34687639.

11. Bakulski KM, Seo YA, Hickman RC, Brandt D, Vadari HS, Hu H, Park SK. Heavy Metals Exposure and Alzheimer's Disease and Related Dementias. J Alzheimers Dis. 2020;76(4):1215-1242. doi: 10.3233/JAD-200282. PMID: 32651318; PMCID: PMC7454042.

12. Kim H, Harrison FE, Aschner M, Bowman AB. Exposing the role of metals in neurological disorders: a focus on manganese. Trends Mol Med. 2022 Jul;28(7):555-568. doi: 10.1016/j.molmed.2022.04.011. Epub 2022 May 22. PMID: 35610122; PMCID: PMC9233117.

13. Kim H, Harrison FE, Aschner M, Bowman AB. Exposing the role of metals in neurological disorders: a focus on manganese. Trends Mol Med. 2022 Jul;28(7):555-568. doi: 10.1016/j.molmed.2022.04.011. Epub 2022 May 22. PMID: 35610122; PMCID: PMC9233117.

14. Lin M, Colon-Perez LM, Sambo DO, Miller DR, Lebowitz JJ, Jimenez-Rondan F, Cousins RJ, Horenstein N, Aydemir TB, Febo M, Khoshbouei H. Mechanism of Manganese Dysregulation of Dopamine Neuronal Activity. J Neurosci. 2020 Jul 22;40(30):5871-5891. doi: 10.1523/JNEUROSCI.2830-19.2020. Epub 2020 Jun 23. PMID: 32576620; PMCID: PMC7380961.

15. Ruiz-Azcona L, Fernández-Olmo I, Expósito A, Markiv B, Paz-Zulueta M, Parás-Bravo P, Sarabia-Cobo C, Santibáñez M. Impact of Environmental Airborne Manganese Exposure on Cognitive and Motor Functions in Adults: A Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2021 Apr 13;18(8):4075. doi: 10.3390/ijerph18084075. PMID: 33924318; PMCID: PMC8068914.

16. Aspli KT, Holmøy T, Flaten TP, Whist JE, Aaseth JO. Skogholt's disease-A tauopathy precipitated by iron and copper? J Trace Elem Med Biol. 2022 Mar;70:126915. doi: 10.1016/j.jtemb.2021.126915. Epub 2021 Dec 16. PMID: 34959013.

17. Zhang Y, Zhou Q, Lu L, Su Y, Shi W, Zhang H, Liu R, Pu Y, Yin L. Copper Induces Cognitive Impairment in Mice via Modulation of Cuproptosis and CREB Signaling. Nutrients. 2023 Feb 15;15(4):972. doi: 10.3390/nu15040972. PMID: 36839332; PMCID: PMC9958748.

18. Pal I, Dey SG. The Role of Heme and Copper in Alzheimer's Disease and Type 2 Diabetes Mellitus. JACS Au. 2023 Feb 17;3(3):657-681. doi: 10.1021/jacsau.2c00572. PMID: 37006768; PMCID: PMC10052274.

19. Hureau C. Can the level of copper in the hippocampus witness type-II diabetes versus Alzheimer's disease? EBioMedicine. 2023 Jan;87:104403. doi: 10.1016/j.ebiom.2022.104403. Epub 2022 Dec 13. PMID: 36516609; PMCID: PMC9768223.

20. Kenkhuis B, Bush AI, Ayton S. How iron can drive neurodegeneration. Trends Neurosci. 2023 May;46(5):333-335. doi: 10.1016/j.tins.2023.02.003. Epub 2023 Feb 24. PMID: 36842947.

21. Xu Y, Zhao J, Zhao Y, Zhou L, Qiao H, Xu Q, Liu Y. The role of ferroptosis in neurodegenerative diseases. Mol Biol Rep. 2023 Feb;50(2):1655-1661. doi: 10.1007/s11033-022-08048-y. Epub 2022 Nov 16. PMID: 36385663.

22. Lee J, Hyun DH. The Interplay between Intracellular Iron Homeostasis and Neuroinflammation in Neurodegenerative Diseases. Antioxidants (Basel). 2023 Apr 12;12(4):918. doi: 10.3390/antiox12040918. PMID: 37107292; PMCID: PMC10135822.

23. Gleason A, Bush AI. Iron and Ferroptosis as Therapeutic Targets in Alzheimer's Disease. Neurotherapeutics. 2021 Jan;18(1):252-264. doi: 10.1007/s13311-020-00954-y. Epub 2020 Oct 27. PMID: 33111259; PMCID: PMC8116360.

24. Masaldan S, Bush AI, Devos D, Rolland AS, Moreau C. Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration. Free Radic Biol Med. 2019 Mar;133:221-233. doi: 10.1016/j.freeradbiomed.2018.09.033. Epub 2018 Sep 25. PMID: 30266679.

25. Ayton S, Wang Y, Diouf I, Schneider JA, Brockman J, Morris MC, Bush AI. Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology. Mol Psychiatry. 2020 Nov;25(11):2932-2941. doi: 10.1038/s41380-019-0375-7. Epub 2019 Feb 18. PMID: 30778133; PMCID: PMC6698435.

26. Wang T, Xu SF, Fan YG, Li LB, Guo C. Iron Pathophysiology in Alzheimer's Diseases. Adv Exp Med Biol. 2019;1173:67-104. doi: 10.1007/978-981-13-9589-5_5. PMID: 31456206.

27. Ong WY, Farooqui AA. Iron, neuroinflammation, and Alzheimer's disease. J Alzheimers Dis. 2005 Nov;8(2):183-200; discussion 209-15. doi: 10.3233/jad-2005-8211. PMID: 16308487.

28. Smith MA, Zhu X, Tabaton M, Liu G, McKeel DW Jr, Cohen ML, Wang X, Siedlak SL, Dwyer BE, Hayashi T, Nakamura M, Nunomura A, Perry G. Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment. J Alzheimers Dis. 2010;19(1):363-72. doi: 10.3233/JAD-2010-1239. PMID: 20061651; PMCID: PMC2842004.

29. Grünblatt E, Bartl J, Riederer P. The link between iron, metabolic syndrome, and Alzheimer's disease. J Neural Transm (Vienna). 2011 Mar;118(3):371-9. doi: 10.1007/s00702-010-0426-3. Epub 2010 Jun 17. PMID: 20556444.

30. Mohamed M Elseweidy et al.Vitamin D alleviates cognitive dysfunction and brain damage induced by copper sulfate intake in experimental rats: focus on its combination with donepezil. Naunyn Schmiedebergs Arch Pharmacol. 2023 Mar 3. doi: 10.1007/s00210-023-02449-x. Online, ahead of print.