New Study: Keto-Like Diet Linked to Heart Disease! Low Carb Mediterranean Diet Healthy Alternative!
By Steve Blechman
It was reported March 6, 2023, by Medical Xpress.com that, “The ketogenic or ‘keto diet’, which involves consuming very low amounts of carbohydrates and high amounts of fats, has been gaining popularity. However, a new study presented at the American College of Cardiology's Annual Scientific Sessions together with the World Congress of Cardiology suggests that a ‘keto like’ diet may be associated with higher blood levels of ‘bad’ cholesterol and a twofold heightened risk of cardiovascular events such as chest pain (angina), blocked arteries requiring stenting, heart attacks and strokes. The study is titled “Association of Low-Carbohydrate High-Fat (Ketogenic) Diet With Plasma Lipid Levels and Cardiovascular Risk In A Population-Based Cohort.”
The lead author of the study, Lulia Latan MD, Ph.D. said, “Our study found that regular consumption of a self-reported diet low in carbohydrate and high in fat was associated with increased levels of LDL cholesterol or ‘bad’ cholesterol – and a higher risk of heart disease.” Dr. Latan also said, “To our knowledge, our study is one of the first to examine the association between this type of dietary pattern and cardiovascular outcomes.”
Past research studies have reported that low-carbohydrate, high-fat (LCHF) diets rich in saturated fats can elevate levels of LDL cholesterol. “While elevated LDL cholesterol is a known risk factor for heart disease (caused by atherosclerosis, a buildup of cholesterol in the coronary arteries), the effects of LCHF diet on risk for heart disease and stroke have not been well studied,” Latan said.
Dr. Latan further said, “Among the participants on the LCHF diet, we found that those with the highest levels of LDL cholesterol were at the highest risk for a cardiovascular event.”
“Our findings suggest that people who are considering going on an LCHF diet should be aware that doing so could lead to an increase in their levels of LDL cholesterol.”
A new breakthrough study published in the prestigious journal Lancet on March 3rd, 2023 stated that “inflammation and hyper lipidemia jointly contributed to atherothrombotic disease.” The findings were based on the analysis of three randomized trials involving 33,245 patients.
The Lancet study “aimed to evaluate the relative importance of high-sensitivity C-reactive protein (CRP) and low-density lipoprotein cholesterol (LDLC) as determinants of risk for major adverse cardiovascular events, cardiovascular death and all cause death among patients receiving statins.”
The important findings of the study are “Among patients receiving contemporary statins, inflammation assessed by high-sensitivity CRP was a stronger predictor for risk of future cardiovascular events and death than cholesterol assessed by LDLC. These data have implications for the selection of adjunctive treatments beyond statin therapy and suggests that combined use of aggressive lipid-lowering and inflammation-inhibiting therapies may be needed to further reduce atherosclerotic risk.”
I have been an advocate of the heart-healthy and anti-inflammatory Mediterranean diet for over 25 years! A healthy diet and lifestyle changes, such as following the Mediterranean Diet along with exercise, has been shown in the scientific research to safely prevent and lower the risk of gaining weight, obesity, metabolic syndrome, diabetes, hypertension, and cardiovascular disease. Many antioxidant foods rich in polyphenols are abundant in the Mediterranean diet such as extra-virgin olive oil, fruits, nuts, red wine, tea, and coffee.
In a study of more 90,000 people who were followed for 28 years, published on Monday, January 10th in the Journal of the American College of Cardiology, Harvard researchers reported that “adding less than a tablespoon of olive oil to their diet lowers a person’s risk for death from heart or lung disease, as well as brain disorders and cancer.” (UPI News)
United Press International (UPI News) reported, “Compared to participants who rarely or never consumed olive oil, those who added one-half tablespoon or more to their diet daily had a 19% lower risk for death from heart disease, the data showed.”
“This level of olive oil consumption was also associated with a 29% lower risk for death from neurodegenerative diseases such as Alzheimer's and Parkinson's, according to the researchers.”
“In addition, substituting 10 grams, or just under one tablespoon per day of olive for the same amount of margarine, butter, mayonnaise and dairy lowered a person’s risk for early death from all causes by up to 34%,” they said.
The Mediterranean diet is high in fish containing omega-3 fatty acids, in addition to antioxidant-rich vegetables, red wine and berries rich in polyphenols, beans, lentils, nuts, legumes and extra-virgin-olive oil that are rich in healthy monounsaturated polyunsaturated fats and low in saturated fats. A study by Harvard researchers and reported by the American Heart Association (March 5, 2020) and published in the Journal of the American College of Cardiology (March 2020) found that as little as half a tablespoon of olive oil a day was linked to significant decrease in cardiovascular disease. Research has shown that omega-3 fatty acids found in fatty fish such as salmon have potent anti-inflammatory properties and reduce inflammation and protect against heart disease.
Research has shown that inflammation is a major risk factor for cardiovascular disease. Research has shown that the traditional Mediterranean diet can reduce inflammation and improve cardiovascular health (Nutrients, August 9, 2020). Sixteen years ago, the ATTICA Study (J Am Coll Cardiol, July 2004) found that the Mediterranean diet was associated with a 20% lower C-reactive protein (CRP) and 17% lower levels of interleukin-6 (IL-6). CRP and IL-6 are elevated in systemic inflammation in the body. This was an observational study and demonstrated an association but not proof of cause and effect like a randomized, double-blind clinical trial; also, a similar study a year later called the Nurses’ Cohort in the USA (Am J Clin Nut, July 2005) was associated to a 24% lower C-reactive protein and 16% lower levels of interleukin-6 (IL-6). These very well-conducted observational studies were later confirmed by a randomized clinical trial (PREDIMED pilot study). The Mediterranean diet, when supplemented with extra-virgin olive oil for three months and followed by adults, reduced C-reactive protein. The Mediterranean diet, as I mentioned, was supplemented with extra-virgin oil containing monounsaturated fats and polyphenols and lowered low-grade inflammation implicated in the mechanism leading to atherosclerotic disease (Nutr Metab, September 2014). The PREDIMED trial later involving 1,139 high-risk cardiovascular adults further confirmed a dose-dependent anti-inflammatory of the Mediterranean diet rich in polyphenols based on measuring inflammatory biomarkers such as C-reactive protein and interleukin-6 (Br J Clin Pharmaca, January 2017). A later study (CANTOS trial) found that a monoclonal antibody that reduces C-reactive protein and interleukin-6, and inflammation, further confirmed the inflammatory hypothesis in atherosclerosis and cardiovascular disease without lowering blood lipids (N Engel J Med, Jan 1999, Endocrinol Diabet Nutr, Nov 2017). The Mediterranean diet containing extra-virgin olive oil, fruits, and red wine is rich in polyphenols with potent anti-inflammatory properties.
A breakthrough, long-term diet study was published in the American Heart Association Journal Circulation on measuring body fat! This diet study used magnetic resonance imaging (MRI) technology for the first time, measuring changes in body and organ fat during 18 months on a Mediterranean/low-carb diet, with and without moderate physical exercise. MRI is a diagnostic technique that produces computerized images of organs and internal body tissues using a magnetic field and radio waves. This is the best approach to date for measuring body fat, compared to weighing people as a result of diet and exercise. The scale, skinfold calipers or underwater weighing are not giving you the whole picture!
The research was conducted between Ben-Gurion University of the Negev and Harvard University. The research group was led by Drs. Iris Shai, Yftach Gepner, Ilan Shelaf and Dan Schwarzfuchs from Ben-Gurion University. Dr. Meir Stampfer was also a lead author for the study and is from the prestigious Harvard University. Dr. Stampfer is a well-known authority on nutrition and obesity. The study analyzed the implementation of positive dietary changes and how this could help in reducing body fat, particularly visceral (abdominal) body fat.
The Mediterranean low-carb diet was significantly superior to low-fat diet in decreasing fat storage, including visceral (deep abdominal) liver and heart fat. High visceral fat has been shown to increase metabolic syndrome, inflammation, cardiovascular disease and diabetes. Losing deep subcutaneous visceral fat, as well as haptic (liver) fat, was associated with improved insulin sensitivity and improved lipid profile.
The low-carb Mediterranean diet was more effective than a low-fat diet in eliminating fat storage. Previous studies have shown that a low-carb Mediterranean diet may be an effective alternative to low-fat diets. It has a more favorable effect on lipids (with low-carb diet) and glycemic control (with Mediterranean diet).
In a groundbreaking, two-year dietary intervention study published in the New England Journal of Medicine, researchers found that the Mediterranean and low-carb diet was an effective alternative to weight loss. It appears to be just as safe, metabolically healthier and more effective compared to a low-fat diet. Consumption of monounsaturated fats (extra-virgin olive oil and nuts) is thought to improve insulin sensitivity, which may explain the favorable effect on blood glucose and insulin levels. Research has shown that nut consumption can enhance weight loss and weight gain (N Engl J Med, 2008).
People who strictly follow the Mediterranean diet tend to have a lower body mass index (BMI), which is a measure of the proportion of weight to height and waist circumference – according to a large population study led by Simona Bertoli from the Nutritional Research Center in Milan, Italy. The Mediterranean diet is high in fish, seafood, antioxidant-rich vegetables, red wine and berries rich in polyphenols, beans, lentils, nuts, legumes and extra-virgin-olive oil (EVOO) that are rich in healthy monounsaturated and polyunsaturated fats and low in saturated fats. Extra-virgin olive oil contains a polyphenol called oleuropein and can increase brown fat thermogenesis.
Brown fat is a special kind of fat cell that generates heat and helps regulate body weight and energy expenditure. The body has two forms of fat – white fat and brown fat. Brown fat burns calories. The more brown fat you have, the more calories you burn. The capability of harnessing one’s one brown fat for fat burning is revolutionary! The ability to get lean by producing extra brown fat and enhancing and activating existing brown fat represents a promising way to burn fat. Several landmark discoveries and approaches to this are being explored at major research centers and universities worldwide, with great excitement. Brown fat research is a hot topic today!
The Thermo Heat® Weight Loss Revolution by Michael Rudolph, Ph.D. provides a calorie-controlled low-carb Mediterranean diet, 30-day meal plan and exercise program. It says that you should limit yourself to 100 grams of carbohydrates per day, or less. Processed food and sugar is off the table! The Thermo Heat® Weight Loss Revolution stresses foods high in monounsaturated and omega-3 polyunsaturated fatty acids. It also recommends thermogenic brown fat-activating herbs and spices instead of salt to flavor food such as garlic, onion, mustard and chili pepper (capsaicin) to name a few. The American Heart Association released a press release on November 9, 2020, which said: “Individuals who consume chili pepper may live longer and may have a significantly reduced risk of dying from cardiovascular disease or cancer, according to preliminary research presented at the American Heart Association’s Scientific Sessions 2020. The meeting was a premier global exchange of the latest scientific advancements, research and evidence-based clinical practice updates in cardiovascular science for health care worldwide.” The meeting was held virtually on November 13, 2020.
Monounsaturated fats are more thermogenic than saturated fats found in high-fat dairy and red meat. Because of ease of compliance, The Thermo Heat® Weight Loss Revolution Mediterranean Diet makes it easy to follow even when dining out. One or two glasses of polyphenol-rich red wine (not white wine, or any other alcoholic beverages) per day can have positive health benefits on the Mediterranean diet. Studies show that olive oil and certain spices (such as capsaicin found in chili peppers) can enhance brown fat and increase thermogenesis. A number of studies have shown that healthy fats from nuts, olive oil and fish, found predominantly in Italian, Greek and Turkish cuisine, have health benefits in the prevention of heart disease, type 2 diabetes, and obesity. Fish oil and omega-3 fats can decrease bodyweight gain and fat accumulation by increasing thermogenesis and energy expenditure. (Clinical Nutrition, 2009; Metabolism - Clinical and Experimental, 2008; International Journal of Obesity, 2002; Nutrition Journal, 2015).
For more authoritative information, see The Thermo Heat® Weight Loss Revolution, by Michael J. Rudolph, Ph.D., including the foreword by Daniel L. Friedman, MD and Eugene B. Friedman, MD. You can click the link to order on Amazon here. The Thermo Heat® Weight Loss Revolution is a groundbreaking scientific plan based on research involving brown fat (BAT). The Thermo Heat® Weight Loss Revolution offers its readers a brown fat, thermogenic and brown-fat-activating-diet, nutrition, supplement(s) and exercise program. You can also get a free PDF version here.
©Published by Advanced Research Media, Inc. 2022
©Reprinted with permission from Advanced Research Media, Inc.
References:
- Keto-like diet may be linked to higher risk of heart disease, cardiac events by American College of Cardiology. March 6, 2023. Medical Xpress https://medicalxpress.com/news/2023-03-keto-like-diet-linked-higher-heart.html
- Ridker PM, Bhatt DL, Pradhan AD, Glynn RJ, MacFadyen JG, Nissen SE; PROMINENT, REDUCE-IT, and STRENGTH Investigators. Inflammation and cholesterol as predictors of cardiovascular events among patients receiving statin therapy: a collaborative analysis of three randomised trials. Lancet. 2023 Mar 3:S0140-6736(23)00215-5. doi: 10.1016/S0140-6736(23)00215-5. Epub ahead of print. PMID: 36893777.
- The benefits of olive oil for health and well-being by University of Seville. February 23, 2023. Medical Xpress https://medicalxpress.com/news/2023-02-benefits-olive-oil-health-well-being.html
- Agarwal P, Leurgans SE, Agrawal S, Aggarwal N, Cherian LJ, James BD, Dhana K, Barnes LL, Bennett DA, Schneider JA. Association of Mediterranean-DASH Intervention for Neurodegenerative Delay and Mediterranean Diets With Alzheimer Disease Pathology. Neurology. 2023 Mar 8:10.1212/WNL.0000000000207176. doi: 10.1212/WNL.0000000000207176. Epub ahead of print. PMID: 36889921.
- Devranis P, Vassilopoulou Ε, Tsironis V, Sotiriadis PM, Chourdakis M, Aivaliotis M, Tsolaki M. Mediterranean Diet, Ketogenic Diet or MIND Diet for Aging Populations with Cognitive Decline: A Systematic Review. Life (Basel). 2023 Jan 6;13(1):173. doi: 10.3390/life13010173. PMID: 36676122; PMCID: PMC9866105.
- Papandreou C, Papagiannopoulos C, Koutsonida M, Kanellopoulou A, Markozannes G, Polychronidis G, Tzakos AG, Fragkiadakis GA, Evangelou E, Ntzani E, Tzoulaki I, Aretouli E, Tsilidis KK. Mediterranean diet related metabolite profiles and cognitive performance. Clin Nutr. 2023 Feb;42(2):173-181. doi: 10.1016/j.clnu.2022.12.012. Epub 2022 Dec 22. PMID: 36599272.
- Grao-Cruces E, Calvo JR, Maldonado-Aibar MD, Millan-Linares MDC, Montserrat-de la Paz S. Mediterranean Diet and Melatonin: A Systematic Review. Antioxidants (Basel). 2023 Jan 24;12(2):264. doi: 10.3390/antiox12020264. PMID: 36829823; PMCID: PMC9951922.
- Andreo-López MC, Contreras-Bolívar V, Muñoz-Torres M, García-Fontana B, García-Fontana C. Influence of the Mediterranean Diet on Healthy Aging. Int J Mol Sci. 2023 Feb 24;24(5):4491. doi: 10.3390/ijms24054491. PMID: 36901921; PMCID: PMC10003249.
- Fatima K, Rashid AM, Memon UAA, Fatima SS, Javaid SS, Shahid O, Zehri F, Obaid MA, Ahmad M, Almas T, Minhas AMK. Mediterranean Diet and its Effect on Endothelial Function: A Meta-analysis and Systematic Review. Ir J Med Sci. 2023 Feb;192(1):105-113. doi: 10.1007/s11845-022-02944-9. Epub 2022 Feb 22. PMID: 35192097; PMCID: PMC9892125.
- Maggi S, Ticinesi A, Limongi F, Noale M, Ecarnot F. The role of nutrition and the Mediterranean diet on the trajectories of cognitive decline. Exp Gerontol. 2023 Mar;173:112110. doi: 10.1016/j.exger.2023.112110. Epub 2023 Feb 2. PMID: 36720373.
- González-Palacios Torres C, Barrios-Rodríguez R, Muñoz-Bravo C, Toledo E, Dierssen T, Jiménez-Moleón JJ. Mediterranean diet and risk of breast cancer: An umbrella review. Clin Nutr. 2023 Apr;42(4):600-608. doi: 10.1016/j.clnu.2023.02.012. Epub 2023 Feb 23. PMID: 36893621.
- Mohajeri M, Mohajery R, Cicero AFG. Adherence to the Mediterranean Diet Association with Serum Inflammatory Factors Stress Oxidative and Appetite in COVID-19 Patients. Medicina (Kaunas). 2023 Jan 26;59(2):227. doi: 10.3390/medicina59020227. PMID: 36837428; PMCID: PMC9968085.
- Nucci D, Nardi M, Cinnirella A, Campagnoli E, Maffeo M, Perrone PM, Shishmintseva V, Grosso FM, Castrofino A, Castaldi S, Romanò L, Gianfredi V. Adherence to Mediterranean Diet and Risk of Pancreatic Cancer: Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2023 Jan 29;20(3):2403. doi: 10.3390/ijerph20032403. PMID: 36767770; PMCID: PMC9915542.
- Mohajeri M, Cicero AFG. Adherence to the Mediterranean Diet Association with Serum Levels of Nitric Oxide, Prostacyclin, and Thromboxane B2 among Prinzmetal Angina Patients and Healthy Persons. Nutrients. 2023 Feb 1;15(3):738. doi: 10.3390/nu15030738. PMID: 36771443; PMCID: PMC9919954.
- Vitale S, Palumbo E, Polesel J, Hebert JR, Shivappa N, Montagnese C, Porciello G, Calabrese I, Luongo A, Prete M, Pica R, Grimaldi M, Crispo A, Esindi N, Falzone L, Mattioli V, Martinuzzo V, Poletto L, Cubisino S, Dainotta P, De Laurentiis M, Pacilio C, Rinaldo M, Thomas G, D'Aiuto M, Serraino D, Massarut S, Ferraù F, Rossello R, Catalano F, Banna GL, Messina F, Gatti D, Riccardi G, Libra M, Celentano E, Jenkins DJA, Augustin LSA. One-year nutrition counselling in the context of a Mediterranean diet reduced the dietary inflammatory index in women with breast cancer: a role for the dietary glycemic index. Food Funct. 2023 Feb 6;14(3):1560-1572. doi: 10.1039/d2fo02198f. PMID: 36655860.
- Clark JS, Dyer KA, Davis CR, Shivappa N, Hébert JR, Woodman R, Hodgson JM, Murphy KJ. Adherence to a Mediterranean Diet for 6 Months Improves the Dietary Inflammatory Index in a Western Population: Results from the MedLey Study. Nutrients. 2023 Jan 11;15(2):366. doi: 10.3390/nu15020366. PMID: 36678237; PMCID: PMC9866776.
- Papandreou P, Gioxari A, Daskalou E, Grammatikopoulou MG, Skouroliakou M, Bogdanos DP. Mediterranean Diet and Physical Activity Nudges versus Usual Care in Women with Rheumatoid Arthritis: Results from the MADEIRA Randomized Controlled Trial. Nutrients. 2023 Jan 28;15(3):676. doi: 10.3390/nu15030676. PMID: 36771382; PMCID: PMC9919932.
- Vijakumaran U, Shanmugam J, Heng JW, Azman SS, Yazid MD, Haizum Abdullah NA, Sulaiman N. Effects of Hydroxytyrosol in Endothelial Functioning: A Comprehensive Review. Molecules. 2023 Feb 16;28(4):1861. doi: 10.3390/molecules28041861. PMID: 36838850; PMCID: PMC9966213.
- Hernández-Hernández A, Oliver D, Martínez-González MÁ, Ruiz-Canela M, Eguaras S, Toledo E, de la Rosa PA, Bes-Rastrollo M, Gea A. Mediterranean Alcohol-Drinking Pattern and Arterial Hypertension in the "Seguimiento Universidad de Navarra" (SUN) Prospective Cohort Study. Nutrients. 2023 Jan 7;15(2):307. doi: 10.3390/nu15020307. PMID: 36678178; PMCID: PMC9865916.
- Henn M, Babio N, Romaguera D, Vázquez-Ruiz Z, Konieczna J, Vioque J, Torres-Collado L, Razquin C, Buil-Cosiales P, Fitó M, Schröder H, Hu FB, Abete I, Zulet MÁ, Fernández-Villa T, Martín V, Estruch R, Vidal J, Paz-Graniel I, Martínez JA, Salas-Salvadó J, Martínez-González MA, Ruiz-Canela M. Increase from low to moderate, but not high, caffeinated coffee consumption is associated with favorable changes in body fat. Clin Nutr. 2023 Apr;42(4):477-485. doi: 10.1016/j.clnu.2023.02.004. Epub 2023 Feb 11. PMID: 36870243.
- American Academy of Neurology. "MIND and Mediterranean diets associated with fewer Alzheimer's plaques and tangles." ScienceDaily. ScienceDaily, 8 March 2023. www.sciencedaily.com/releases/2023/03/230308201051.htm
- Puja Agarwal, Sue E. Leurgans, Sonal Agrawal, Neelum Aggarwal, laurel J Cherian, Bryan D James, Klodian Dhana, Lisa L. Barnes, David A. Bennett, Julie A. Schneider. Association of Mediterranean-DASH Intervention for Neurodegenerative Delay and Mediterranean Diets With Alzheimer Disease Pathology. Neurology, 2023; 10.1212/WNL.0000000000207176 DOI: 10.1212/WNL.0000000000207176
- Consumption of Olive Oil and Risk of Total and Cause-Specific Mortality Among U.S. Adults,
- Journal of the American College of Cardiology. 2022. Marta Guasch-Ferré, Yanping Li, Walter C. Willett, Qi Sun, Laura Sampson, Jordi Salas-Salvadó, Miguel A. Martínez-González, Meir J. Stampfer, Frank B. Hu,. https://doi.org/10.1016/j.jacc.2021.10.041.
- (https://www.sciencedirect.com/science/article/pii/S0735109721081481
- Less than a tablespoon of olive oil lowers death risk, study says. Brian P. Dunleavy. UPI News https://www.newsbreak.com/news/2481827487612/less-than-a-tablespoon-of-olive-oil-lowers-death-risk-study-says?noAds=1&_f=app_share&s=i4
- S. News Reveals Best Diet Rankings for 2022. January 4, 2022. US News & World Report https://www.usnews.com/info/blogs/press-room/articles/2022-01-04/u-s-news-reveals-best-diet-rankings-for-2022
- S. News Reveals Best Diet Rankings for 2021. January 4, 2021. US News & World Report. https://www.usnews.com/info/blogs/press-room/articles/2021-01-04/us-news-reveals-best-diet-rankings-for-2021
- Olive oil may lower heart disease risk. American Heart Association News. March 5, 2020. https://www.heart.org/en/news/2020/03/05/olive-oil-may-lower-heart-disease-risk
- Olive Oil Consumption and Cardiovascular Risk in U.S. Adults. Journal of the American College of Cardiology. Marta Guasch-Ferré, Gang Liu, Yanping Li, Laura Sampson, JoAnn E. Manson, Jordi Salas-Salvadó, Miguel A. Martínez-González, Meir J. Stampfer, Walter C. Willett, Qi Sun, Frank B. Hu. Journal of the American College of Cardiology. April 2020. https://doi.org/10.1016/j.jacc.2020.02.036
- Razquin C, Martinez-Gonzalez MA. A Traditional Mediterranean Diet Effectively Reduces Inflammation and Improves Cardiovascular Health. Nutrients. 2019;11(8):1842. Published 2019 Aug 9. doi:10.3390/nu11081842
- Fish Consumption in Healthy Adults Is Associated with Decreased Circulating Biomarkers of Endothelial Dysfunction and Inflammation during a 6-Year Follow-Up. Bas C. T. van Bussel, Ronald M. A. Henry, Casper G. Schalkwijk, Isabel Ferreira, Edith J. M. Feskens, Martinette T. Streppel, Yvo M. Smulders, Jos W. R. Twisk, Coen D. A. Stehouwer. The Journal of Nutrition, Volume 141, Issue 9, September 2011, Pages 1719-1725, https://doi.org/10.3945/jn.111.139733
- Ratih Wirapuspita Wisnuwardani, Stefaan De Henauw, Marika Ferrari, Maria Forsner, Frédéric Gottrand, Inge Huybrechts, Antonios G Kafatos, Mathilde Kersting, Viktoria Knaze, Yannis Manios, Ascensión Marcos, Dénes Molnár, Joseph A Rothwell, Azahara Iris Rupérez, Augustin Scalbert, Kurt Widhalm, Luis A Moreno, Nathalie Michels, Total Polyphenol Intake Is Inversely Associated with a Pro/Anti-Inflammatory Biomarker Ratio in European Adolescents of the HELENA Study, The Journal of Nutrition, nxaa064, https://doi.org/10.1093/jn/nxaa064
- Spanish Ketogenic Mediterranean diet: a healthy cardiovascular diet for weight loss. Nutrition Journal, 2008, Volume 7, Number 1, Page 1. Joaquín Pérez-Guisado, Andrés Muñoz-Serrano, Ángeles Alonso-Moraga
- Long-term successful weight loss with a combination biphasic ketogenic Mediterranean diet and Mediterranean diet maintenance protocol. Paoli, A., Bianco, A., Grimaldi, K. A., Lodi, A., & Bosco, G. (2013). Nutrients, 5 (12), 5205-17. doi:10.3390/nu5125205
- Effect of ketogenic Mediterranean diet with phytoextracts and low carbohydrates/high-protein meals on weight, cardiovascular risk factors, body composition and diet compliance in Italian council employees. Paoli, A., Cenci, L., & Grimaldi, K. A. (2011). Nutrition journal, 10, 112. doi:10.1186/1475-2891-10-112
- Mediterranean Diet Reduces Risk of Incident Stroke in a Population With Varying Cardiovascular Disease Risk Profiles. Paterson, K. E., Myint, P. K., Jennings, A., Bain, L., Lentjes, M., Khaw, K. T., & Welch, A. A. (Oct 2018). Stroke, 49 (10), 2415-2420. Advance online publication. doi:10.1161/STROKEAHA.117.020258
- Ahmad S, Moorthy MV, Demler OV, et al. Assessment of Risk Factors and Biomarkers Associated With Risk of Cardiovascular Disease Among Women Consuming a Mediterranean Diet. JAMA Netw Open. Dec. 7, 2018;1(8):e185708. doi:10.1001/jamanetworkopen.2018.5708
- Marialaura Bonaccio, Augusto Di Castelnuovo, Simona Costanzo, Mariarosaria Persichillo, Amalia De Curtis, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello. Interaction between Mediterranean diet and statins on mortality risk in patients with cardiovascular disease: Findings from the Moli-sani Study. International Journal of Cardiology, 2018; DOI: 10.1016/j.ijcard.2018.11.117
- Effect of Distinct Lifestyle Interventions on Mobilization of Fat Storage Pools: The CENTRAL MRI Randomized Controlled Trial. Yftach Gepner, Ilan Shelef, Dan Schwarzfuchs, Hila Zelicha, Lilac Tene, Anat Yaskolka Meir, Gal Tsaban, Noa Cohen, Nitzan Bril, Michal Rein, Dana Serfaty, Shira Kenigsbuch, Oded Komy, Arik Wolak, Yoash Chassidim, Rachel Golan, Hilla Avni-Hassid, Avital Bilitzky, Benjamin Sarusi, Eyal Goshen, Elad Shemesh, Yaakov Henkin, Michael Stumvoll, Matthias Blüher, Joachim Thiery, Uta Ceglarek, Assaf Rudich, Meir J. Stampfer and Iris Shai. Circulation 2017;CIRCULATION AHA.117.030501, 2017.
- Zong, G., Li, Y., Wanders, A.J., Alssema, M., Zock, P.L., Willett, W.C., Hu, F.B., Sun, Q. Intake of individual saturated fatty acids and risk of coronary heart disease in US men and women: two prospective longitudinal cohort studies BMJ. 2016;355:i5796.
- Fish consumption may prolong life. ScienceDaily, 18 July 2018. www.sciencedaily.com/releases/2018/07/180718082138.htm
- Zhang, P. Zhuang, W. He, J. N. Chen, W. Q. Wang, N. D. Freedman, C. C. Abnet, J. B. Wang, J. J. Jiao. Association of fish and long-chain omega-3 fatty acids intakes with total and cause-specific mortality: prospective analysis of 421 309 individuals. Journal of Internal Medicine, 2018; DOI: 10.1111/joim.12786
- Dietary Fats and Cardiovascular Disease: A Presidential Advisory From the American Heart Association Frank M. Sacks, MD, FAHA, Chair, Alice H. Lichtenstein, DSc, FAHA, Jason H.Y. Wu, PhD, MSc, Lawrence J. Appel, MD, MPH, FAHA, Mark A. Creager, MD, FAHA, Penny M. Kris-Etherton, PhD, RD, FAHA, Michael Miller, MD, FAHA, Eric B. Rimm, ScD, FAHA, Lawrence L. Rudel, PhD, FAHA, Jennifer G. Robinson, MD, MPH, FAHA, Vice Chair, Neil J. Stone, MD, FAHA, and Linda V. Van Horn, PhD, RD, FAHA, Vice Chair On behalf of the American Heart Association.
- Mediterranean Diet Reduces Risk of Incident Stroke in a Population With Varying Cardiovascular Disease Risk Profiles. Paterson, K. E., Myint, P.K., Jennings, A., Bain, L., Lentjes, M., Khaw, K.T., & Welch, A.A. (Oct 2018). Stroke, 49 (10), 2415-2420. Advance online publication. doi:10.1161/STROKEAHA.117.020258
- Adherence to the Mediterranean diet attenuates inflammation and coagulation process in healthy adults: The Attica study. Journal of the American College of Cardiology. 2004. https://doi.org/10.1016/j.jacc.2004.03.039.
- Teresa T Fung, Marjorie L McCullough, PK Newby, JoAnn E Manson, James B Meigs, Nader Rifai, Walter C Willett, Frank B Hu, Diet-quality scores and plasma concentrations of markers of inflammation and endothelial dysfunction, The American Journal of Clinical Nutrition, Volume 82, Issue 1, July 2005, Pages 163-173, https://doi.org/10.1093/ajcn/82.1.163
- Estruch R, Martínez-González MA, Corella D, et al. Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trial [published correction appears in Ann Intern Med. 2018 Aug 21;169(4):270-271]. Ann Intern Med. 2006;145(1):1-11. doi:10.7326/0003-4819-145-1-200607040-00004
- Schwingshackl L, Christoph M, Hoffmann G. Effects of Olive Oil on Markers of Inflammation and Endothelial Function-A Systematic Review and Meta-Analysis. Nutrients. 2015;7(9):7651-7675. Published 2015 Sep 11. doi:10.3390/nu7095356
- Medina-Remón A, Casas R, Tressserra-Rimbau A, et al. Polyphenol intake from a Mediterranean diet decreases inflammatory biomarkers related to atherosclerosis: a substudy of the PREDIMED trial. Br J Clin Pharmacol. 2017;83(1):114-128. doi:10.1111/bcp.12986
- Sureda A, Bibiloni MDM, Julibert A, et al. Adherence to the Mediterranean Diet and Inflammatory Markers. Nutrients. 2018;10(1):62. Published 2018 Jan 10. doi:10.3390/nu10010062
- Ruiz-Canela M, Estruch R, Corella D, Salas-Salvadó J, Martínez-González MA. Association of Mediterranean diet with peripheral artery disease: the PREDIMED randomized trial [published correction appears in JAMA. 2018 Dec 4;320(21):2272]. JAMA. 2014;311(4):415-417. doi:10.1001/jama.2013.280618
- Martínez-González MA, Salas-Salvadó J, Estruch R, et al. Benefits of the Mediterranean Diet: Insights From the PREDIMED Study. Prog Cardiovasc Dis. 2015;58(1):50-60. doi:10.1016/j.pcad.2015.04.003
- Primary Prevention of Cardiovascular Disease with a Mediterranean Diet. Ramón Estruch, Emilio Ros, Jordi Salas-Salvadó, et al. The New England Journal of Medicine. Massachusetts Medical Society. Apr 4, 2013 https://www.nejm.org/doi/full/10.1056/NEJMoa1200303
- Anti-inflammatory Therapy with Canakinumab for Atherosclerotic Disease. Paul M Ridker, Brendan M. Everett, Tom Thuren. The New England Journal of Medicine, Sep 21, 2017 https://www.nejm.org/doi/full/10.1056/NEJMoa1707914
- Baker ME, DeCesare KN, Johnson A, Kress KS, Inman CL, Weiss EP. Short-Term Mediterranean Diet Improves Endurance Exercise Performance: A Randomized-Sequence Crossover Trial. J Am Coll Nutr. 2019 Sep-Oct;38(7):597-605. doi: 10.1080/07315724.2019.1568322. Epub 2019 Feb 13. PMID: 30758261.
- David S Ludwig, Stephanie L Dickinson, Beate Henschel, Cara B Ebbeling, David B Allison, Do Lower-Carbohydrate Diets Increase Total Energy Expenditure? An Updated and Reanalyzed Meta-Analysis of 29 Controlled-Feeding Studies, The Journal of Nutrition, nxaa350, https://doi.org/10.1093/jn/nxaa350
- Oleuropein, a Phenolic Compound in Extra Virgin Olive Oil, Increases Uncoupling Protein 1 Content in Brown Adipose Tissue and Enhances Noradrenaline and Adrenaline Secretions in Rats, Journal of Nutritional Science and Vitaminology, Released November 11, 2008 Yuriko Oi-Kano, Teruo Kawada, Tatsuo Watanabe, Fumihiro Koyama, Kenichi Watanabe, Reijirou Senbongi, Kazuo Iwai
- Oleuropein aglycone enhances UCP1 expression in brown adipose tissue in high-fat diet induced by obese rats by activating beta-adrenergic signaling. Yuriko Oi-Kano, Teruo Kawada, Tatsuo Watanabe, Fumihiro Koyama, Kenichi Watanabe, Reijirou Senbongi, Kazuo Iwai, J Nutrit Biochemistry, 2/2017, 209-218
- The influence of the type of dietary fat on postprandial fat oxidation rates: monounsaturated (olive oil) vs saturated fat (cream). LS Piers, KZ Walker, RM Stoney, MJ Soares and K O’Dea. International Journal of Obesity (2002) 26, 814-821 (2002)
- The effect of dietary oleic, linoleic, and linolenic acids on fat oxidation and energy expenditure in healthy men. Jones, Peter J.H. et al. Metabolism - Clinical and Experimental, Volume 57, Issue 9, 1198-1203
- Nut intake and 5-year changes in body weight and obesity risk in adults: results from the EPIC-PANACEA study. European Journal of Nutrition, 2017, Page 1 Heinz Freisling, Hwayoung Noh, Nadia Slimani