NEW STUDY! The Miracle Powers of AML THERMO HEAT FAT BURNING PROTEIN with Coffee!
By Steve Blechman
I consider coffee the healthiest beverage on the planet. It is loaded with phenolic antioxidants, which have been shown to be beneficial in the prevention of heart disease, cancer, diabetes and living a longer life. In fact— the darker the roast, the better! There are over 200 studies that find drinking two to three cups of coffee per day is associated with a lower risk of death and heart disease compared to drinking no coffee. Also, coffee drinking is associated with a lower risk of many cancers, liver disease, diabetes and dementia. A recent study (Food Func., 2018, Jan. 23) found that coffee consumption promotes muscle hypertrophy. The study showed that by inhibiting myostatin expression and increasing IGF-1, coffee increases grip strength. Another study (Nutrition Journal, 2012) found that coffee drinking not only increases longevity, but also elevates testosterone levels! There are so many potential “miracle powers of coffee!”
This week on Monday, June 24, 2019 in the prestigious journal Nature Scientific Reports a breakthrough weight loss/fat loss study was published entitled: “Coffee Exposure Induces Browning Features in Adipose Tissue In Vitro and In Vivo.” The researchers said, “It is the first study in humans to show that something like a cup of coffee can have a direct effect on brown fat functions.” British researchers from the University of Nottingham found that one cup of coffee containing only 65mg of caffeine can activate brown fat. Brown fat is an organ that is extremely metabolically active. It’s like a generator that produces heat, which helps burn more calories. We only have 50 to 100 grams of brown fat, mainly located behind the neck and scapula. Brown fat produces 300 times more heat than our muscles or any organ in the body! It is loaded with mitochondria, the powerhouse of the cell. The body has two types of fat: white fat and brown fat. The more brown fat you have and activated, the more calories you burn! If we can increase the amount of brown fat or activate more brown fat cells, the more calories you will burn over a 24-hour period.
Researchers at the University of Nottingham first tested stem cells in the laboratory of mice and humans, which activated brown fat activity. They then tested humans by ingesting one cup of coffee containing 65mg of caffeine. The ingestion of just one cup of coffee activated brown fat in the neck and scapula, which was measured by using advanced thermal imaging technology. “The potential implications of our results are pretty big, as obesity is a major health concern for society,” said study co-director and University of Nottingham professor Michael Simmonds, Ph.D. “We also have a growing diabetes epidemic and brown fat could potentially be a part of the solution in tackling them.” (Inverse.com June 25, 2019)
The researchers found that drinking coffee activates brown fat thermogenesis, and energy expenditure. I was the first over 30 years ago as Head of Product Development for 26 years at Twinlab and launched Ripped Fuel: the first ephedra caffeine thermogenic fat burner! I was also first to launch ephedra-free Ripped Fuel containing a combination of p-synephrine from citrus aurantium combined with caffeine. I was also awarded a United States patent for this weight loss product.
Over the last few years, I launched AML® THERMO HEAT, the most scientifically advanced brown fat and thermogenic supplement line ever developed! One of those products, AML™ THERMO HEAT® FAT BURNING PROTEIN, contains nutrients that have been shown to increase brown fat activation and thermogenesis. Nitric oxide has been shown to activate BAT and thermogenesis. Nitric oxide and nitric oxide precursors such as citrulline have been shown to increase BAT and thermogenesis. Grapeskin extract has been shown to increase nitric oxide production. Polyphenols are being studied for their role in fat metabolism and obesity management. Folic acid also boosts nitric oxide availability, by increasing BH4 and decreasing homocysteine levels. Research has shown that folic acid can lower homocysteine levels, increase insulin sensitivity and lower fasting insulin levels in type 2 diabetes. Medium-chain triglycerides (MCTs), grains of paradise (40mg - standardized for 12% paradol, a clinically effective dose) and BioPerine® black pepper fruit extract are all included for further activation of brown adipose tissue (BAT) and thermogenesis. Grains of paradise, a spice containing 6-paradol, like chili peppers containing capsaicin, activate BAT, increase whole-body energy expenditure and decrease visceral fat (deep abdominal fat) in humans. Allulose is added as a natural, low-calorie, fat-burning, thermogenic sweetener. It is approved for low-sugar/low-carb or ketogenic diets. Allulose does not impact blood sugar or insulin levels.
Don’t think you can lose weight and enhance fat loss by taking just one fat=burning pill a day, or by ingesting just one cup of coffee daily! That’s why I developed the AML®THERMO HEAT ADVANCED DIET, NUTRITION, SUPPLEMENTATION AND EXERCISE PROGRAM for maximizing brown fat, brown fat activity and 24-hour energy expenditure! Check out the AML ®THERMO HEAT LOW-CARB MEDITERANEAN DIET and why I feel it’s the best overall diet for weight loss, fat loss and optimal health! It’s rich in healthy fats and not bad fats that activate thermogenesis (see my other article on good fats and bad fats.) The capability of harnessing one’s own brown fat for fat burning is revolutionary! The ability to get lean by producing extra brown fat and enhancing and activating existing brown fat represents a promising way to burn fat. Several landmark discoveries and approaches to this are being explored at major research centers and universities worldwide, with great excitement! Brown fat research is a hot topic today! In fact, cold temperatures and certain nutrients have been shown to trigger brown fat activity! Of course, cold temperature exposure is not a practical way to activate brown fat because of discomfort.
The book entitled The Thermo Heat® Weight Loss Revolution by Michael Rudolph, Ph.D. provides in chapter 2, The Thermo Heat HIIT Workout, plus The Thermo Heat Total-Body Fat-Incinerating Exercise Plan, a comprehensive program along with a calorie-controlled, low-carb Mediterranean diet, and 30-day meal plan. It says that you should limit yourself to 100 grams of carbohydrates per day, or less. If you want to follow the ketogenic diet, carbohydrates should be kept to less than 50 grams per day. Processed food and sugar is off the table! The Thermo Heat® Weight Loss Revolution stresses foods high in monounsaturated and omega-3 polyunsaturated fatty acids. The book does not recommend saturated fats or coconut oil. Studies have shown that coconut oil taken with meals does not increase thermogenesis (Nutr Metab 2017). It also recommends thermogenic brown fat-activating herbs and spices instead of salt to flavor food— such as garlic, onion, mustard and chili pepper (capsaicin) to name a few. Monounsaturated fats are more thermogenic than saturated fats found in high-fat dairy and red meat. Because of ease of compliance, The Thermo Heat® Weight Loss Revolution Mediterranean diet makes it easy to follow even when dining out. One or two glasses of polyphenol-rich red wine (not white wine, or any other alcoholic beverages) per day can have positive health benefits on the Mediterranean diet. Studies show that olive oil and certain spices can enhance brown fat and increase thermogenesis. A number of studies have shown that healthy fats from nuts, olive oil and fish, found predominantly in Italian, Greek and Turkish cuisine, have health benefits in the prevention of heart disease, type 2 diabetes and obesity. Fish oil and omega-3 fats can decrease bodyweight gain and fat accumulation by increasing thermogenesis and energy expenditure. (Clinical Nutrition, 2009; Metabolism: Clinical and Experimental, 2008; International Journal of Obesity, 2002)
For more authoritative information, see The Thermo Heat® Weight Loss Revolution by Michael J. Rudolph, Ph.D., including the foreword by Daniel L. Friedman, MD and Eugene B. Friedman, MD. You can click the link to order on Amazon here. The Thermo Heat® Weight Loss Revolution is a groundbreaking scientific plan based on research involving brown fat (BAT) and offers its readers a brown fat, thermogenic and brown-fat-activating-diet, nutrition, supplement(s) and exercise program. You can also get a free PDF version here
In conclusion, overwhelmingly, the research has clearly shown that coffee is a healthy beverage with almost miraculous powers! That is, of course, without the cream and sugar! Coffee may prevent certain diseases, burn fat, boost lean body mass, improve cognitive function and exercise performance! Become a FAT BURNING MACHINE, take a scoop of AML™ THERMO HEAT® FAT BURNING PROTEIN with your morning coffee on an empty stomach or 30 minutes before a meal! We have delicious flavors in Chocolate Fudge and Vanilla Cream – they taste amazing! AML ™ THERMO HEAT® FAT BURNING PROTEIN† is an advanced scientifically designed protein and amino acid drink. As part of a calorie-restricted diet and exercise (aerobic and resistance training) program, it can help enhance fat loss and preserve lean body mass when following a low-calorie, low-carbohydrate or ketogenic diet. A healthy weight loss is one that enhances the reduction of body fat and preserves lean body mass while dieting. You will be pleased with the results!
References:
- Caffeine exposure induces browning features in adipose tissue in vitro and in vivo. Ksenija Velickovic, Declan Wayne, Hilda Anaid Lugo Leija, Ian Bloor, David E. Morris, James Law, Helen Budge, Harold Sacks, Michael E. Symonds & Virginie Sottile. June 24, 2019. Nature Scientific Reports volume 9, Article number: 9104 (6/24/2019)
- https://www.inverse.com/article/57059-coffee-brown-fat-caffeine-weight-loss Inverse.com June 25, 2019. Weight Loss Study Reveals Coffee’s Role in Burning One Kind of Body Fat by Sara Sloat.
- Yang YJ, Son HJ, et al. Coffee consumption promotes skeletal muscle hypertrophy and myoblast differentiation. Food Funct 2018, 9, 1102. DOI: 10.1039/C7FO01683B.
- Wedick N, Mantzoros C, et al. The effects of caffeinated and decaffeinated coffee on sex hormone-binding globulin and endogenous sex hormone levels: a randomized controlled trial. Nutrition Journal, 201211:86 https://doi.org/10.1186/1475-2891-11-86. Wedick et al.; licensee BioMed Central Ltd. 2012 Received June 14, 2012; Accepted October 16, 2012; Published October 19, 2012
- Symonds, M. E., Aldiss, P., Pope, M. & Budge, H. Recent advances in our understanding of brown and beige adipose tissue: the good fat that keeps you healthy. F1000Res 7, https://doi.org/10.12688/f1000research.14585.1 (2018).
- Ouellet, V. et al. Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. J Clin Invest 122, 545–552, https://doi.org/10.1172/JCI60433 (2012).
- van Marken Lichtenbelt, W. D. et al. Cold-activated brown adipose tissue in healthy men. N Engl J Med 360, 1500-1508, https://doi. org/10.1056/NEJMoa0808718 (2009).
- Darre, L. & Domene, C. Binding of Capsaicin to the TRPV1 Ion Channel. Mol Pharm 12, 4454–4465, https://doi.org/10.1021/acs. molpharmaceut.5b00641 (2015)
- Derbenev, A. V. & Zsombok, A. Potential therapeutic value of TRPV1 and TRPA1 in diabetes mellitus and obesity. Semin Immunopathol 38, 397-406, https://doi.org/10.1007/s00281-015-0529-x (2016).
- Luo, Z. et al. TRPV1 activation improves exercise endurance and energy metabolism through PGC-1alpha upregulation in mice. Cell Res 22, 551-564, https://doi.org/10.1038/cr.2011.205 (2012).
- Astrup, A. et al. Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers. Am J Clin Nutr 51, 759-767, https://doi.org/10.1093/ajcn/51.5.759 (1990).
- Dulloo, A. G., Geissler, C. A., Horton, T., Collins, A. & Miller, D. S. Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and post obese human volunteers. Am J Clin Nutr 49, 44-50, https://doi.org/10.1093/ajcn/49.1.44 (1989).
- Kogure, A. et al. Effects of caffeine on the uncoupling protein family in obese yellow KK mice. Clin Exp Pharmacol Physiol 29, 391-394 (2002).
- Okano, J., Nagahara, T., Matsumoto, K. & Murawaki, Y. Caffeine inhibits the proliferation of liver cancer cells and activates the MEK/ ERK/EGFR signaling pathway. Basic Clin Pharmacol Toxicol 102, 543-551, https://doi.org/10.1111/j.1742-7843.2008.00231.x (2008).
- Law, J. et al. Thermal Imaging is a Noninvasive Alternative to PET/CT for Measurement of Brown Adipose Tissue Activity in Humans. J Nucl Med 59, 516-522, https://doi.org/10.2967/jnumed.117.190546 (2018).
- Yoshioka, K., Yoshida, T., Kamanaru, K., Hiraoka, N. & Kondo, M. Caffeine activates brown adipose tissue thermogenesis and metabolic rate in mice. J Nutr Sci Vitaminol (Tokyo) 36, 173-178 (1990).
- Acute effects of three high-fat meals with different fat saturations on energy expenditure, substrate oxidation and satiety. Casas-Agustench, P. et al. Clinical Nutrition, Volume 28, Issue 1, 39-45 2009
- The effect of dietary oleic, linoleic, and linolenic acids on fat oxidation and energy expenditure in healthy men. Jones, Peter J.H. et al. Metabolism - Clinical and Experimental, Volume 57, Issue 9, 1198-1203
- The influence of the type of dietary fat on postprandial fat oxidation rates: monounsaturated (olive oil) vs saturated fat (cream). LS Piers, KZ Walker, RM Stoney, MJ Soares and K O’Dea. International Journal of Obesity (2002) 26, 814-821 (2002)
- Tyler A Churchward-Venne, Leigh Breen, Danielle M Di Donato, Amy J Hector, Cameron J Mitchell, Daniel R Moore, Trent Stellingwerff, Denis Breuille, Elizabeth A Offord, Steven K Baker, Stuart M Phillips, Leucine supplementation of a low-protein mixed macronutrient beverage enhances myofibrillar protein synthesis in young men: a double-blind, randomized trial, The American Journal of Clinical Nutrition, Volume 99, Issue 2, February 2014, Pages 276-286, https://doi.org/10.3945/ajcn.113.068775
- Chunzi Liang, Benjamin J Curry, Patricia L Brown and Michael B. Zemel, “Leucine Modulates Mitochondrial Biogenesis and SIRT1-AMPK Signaling in C2C12 Myotubes,” Journal of Nutrition and Metabolism, vol. 2014, Article ID 239750, 11 pages, 2014. https://doi.org/10.1155/2014/239750.
- Impact of 3-week citrulline supplementation on postprandial protein metabolism in malnourished older patients: The Ciproage randomized controlled trial. Bouillanne, Olivier et al. Clinical Nutrition, Volume 38, Issue 2, 564-574. April 2019.
- Nitric oxide and mitochondrial biogenesis. Enzo Nisoli, Michele O. Carruba. J Cell Sci 2006 119: 2855-2862; doi: 10.1242/jcs.03062
- Allerton, T.D.; Proctor, D.N.; Stephens, J.M.; Dugas, T.R.; Spielmann, G.; Irving, B.A. l-Citrulline Supplementation: Impact on Cardiometabolic Health. Nutrients 2018, 10, 921.
- Yoshitomi H, Momoo M, Ma X, et al. L-Citrulline increases hepatic sensitivity to insulin by reducing the phosphorylation of serine 1101 in insulin receptor substrate-1. BMC Complement Altern Med. 2015;15:188. Published 2015 Jun 18. doi:10.1186/s12906-015-0706-4.
- Inflammatory markers response to citrulline supplementation in patients with non-alcoholic fatty liver disease: a randomized, double blind, placebo-controlled, clinical trial. Zahra Darabi, Mina Darand, Zahra Yari, Mehdi Hedayati, Amirhosein Faghihi, Shahram Agah and Azita Hekmatdoost. BMC Research.2019/12:89 https://doi.org/10.1186/s13104-019-4130-6.
- Villareal MO, Matsukawa T, Isoda H. L-Citrulline Supplementation-Increased Skeletal Muscle PGC-1alpha Expression is Associated With Exercise Performance and Increased Skeletal Muscle Weight [published online ahead of print, 2018 Jun 25]. Mol Nutr Food Res. 2018;62(14):e1701043. doi:10.1002/mnfr.20170104.
- Cliff J. d C. Harvey, Grant M. Schofield, Micalla Williden, and Joseph A. McQuillan.“The Effect of Medium Chain Triglycerides on Time to Nutritional Ketosis and Symptoms of Keto-Induction in Healthy Adults: A Randomised Controlled Clinical Trial,” Journal of Nutrition and Metabolism, vol. 2018, Article ID 2630565, 9 pages, 2018. https://doi.org/10.1155/2018/2630565.
- Li H, Xu M, Lee J, He C and Xie Z. (2012). Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice. American Journal of Physiology - Endocrinology and Metabolism, 303(10), E1234-E1244. http://doi.org/10.1152/ajpendo.00198.2012
- Tsuboi T, Maeda M, Hayashi T. Administration of L-arginine plus L-citrulline or L-citrulline alone successfully retarded endothelial senescence. PLoS One. 2018;13(2):e0192252. Published 2018 Feb 7. doi:10.1371/journal.pone.0192252
- Miriam E. Clegg (2010) Medium-chain triglycerides are advantageous in promoting weight loss although not beneficial to exercise performance, International Journal of Food Sciences and Nutrition, 61:7, 653-679, DOI: 10.3109/09637481003702114.
- Romero, M. J., Platt, D. H., Caldwell, R. B. and Caldwell, R. W. (2006), Therapeutic Use of Citrulline in Cardiovascular Disease. Cardiovascular Drug Reviews, 24: 275-290. doi:10.1111/j.1527-3466.2006.00275.x
- Zhang Y, Guo K, LeBlanc RE, Loh D, Schwartz GJ, Yu YH. Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms. Diabetes 2007; 56: 164754.
- Grape seed and skin extract mitigates heart and liver oxidative damage induced by a high-fat diet in the rat: gender dependency. Kamel Charradi, Mohamed Mahmoudi, Salem Elkahoui, Ferid Limam, Ezzedine Aouani. Canadian Journal of Physiology and Pharmacology, 2013, 91:1076-1085, https://doi.org/10.1139/cjpp-2013-0225
- Grape seed and skin extract mitigates heart and liver oxidative damage induced by a high-fat diet in the rat: gender dependency. Kamel Charradi, Mohamed Mahmoudi, Salem Elkahoui, Ferid Limam, Ezzedine Aouani. Canadian Journal of Physiology and Pharmacology, 2013, 91:1076-1085, https://doi.org/10.1139/cjpp-2013-0225.
- Grape seed and skin extract mitigates heart and liver oxidative damage induced by a high-fat diet in the rat: gender dependency. Kamel Charradi, Mohamed Mahmoudi, Salem Elkahoui, Ferid Limam, Ezzedine Aouani. Canadian Journal of Physiology and Pharmacology, 2013, 91:1076-1085, https://doi.org/10.1139/cjpp-2013-0225
- Joffin N, Jaubert AM, Bamba J, Barouki R, Noirez P, Forest C. Acute induction of uncoupling protein 1 by citrulline in cultured explants of white adipose tissue from lean and high-fat-diet-fed rats. Adipocyte. 2015;4(2):129-34. Published 2015 Jan 7. doi:10.4161/21623945.2014.989748
- Joffin, N., Jaubert, A., Durant, S., Bastin, J., De Bandt, J., Cynober, L., Moinard, C., Coumoul, X., Forest, C. and Noirez, P. (2014), Citrulline reduces glyceroneogenesis and induces fatty acid release in visceral adipose tissue from overweight rats. Mol. Nutr. Food Res., 58: 2320-2330. doi:10.1002/mnfr.201400507
- Salehpour A, Hosseinpanah F, Shidfar F, et al. A 12-week double-blind randomized clinical trial of vitamin D₃ supplementation on body fat mass in healthy overweight and obese women. Nutr J. 2012;11:78. Published 2012 Sep 22. doi:10.1186/1475-2891-11-7
- Vitamin D decreases adipocyte lipid storage and increases NAD-SIRT1 pathway in 3T3-L1 adipocytes. Chang, Eugene; Kim, Yangha. Nutrition, 2016, Vol: 32, Issue: 6, Page: 702-8 10.1016/j.nut.2015.12.032
- Miriam E. Clegg (2010) Medium-chain triglycerides are advantageous in promoting weight loss although not beneficial to exercise performance, International Journal of Food Sciences and Nutrition, 61:7, 653-679, DOI: 10.3109/09637481003702114
- LaBarrie J, St-Onge MP. A coconut oil-rich meal does not enhance thermogenesis compared to corn oil in a randomized trial in obese adolescents. Insights Nutr Metab. 2017;1(1):30-3
- Farhat, G., Drummond, S., and Al‐Dujaili, E. A. S. (2017) Polyphenols and Their Role in Obesity Management: A Systematic Review of Randomized Clinical Trials. Phytother. Res., 31: 1005-1018. doi: 10.1002/ptr.5830.
- Sugita, J., Yoneshiro, T., Hatano, T., Aita, S., Ikemoto, T., Uchiwa, H., Saito, M. (2013). Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men. British Journal of Nutrition, 110(4), 733-738. doi:10.1017/S0007114512005715
- Jun Sugita, Takeshi Yoneshiro, Yuuki Sugishima, Takeshi Ikemoto, Hideyo Uchiwa, Isao Suzuki, Masayuki Saito, Daily Ingestion of Grains of Paradise (Aframomum melegueta) Extract Increases Whole-Body Energy Expenditure and Decreases Visceral Fat in Humans, Journal of Nutritional Science and Vitaminology, 2014, Volume 60, Issue 1, Pages 22-27, Released April 24, 2014,
- Hattori, H., Yamauchi, K., Onwona‐Agyeman, S. and Mitsunaga, T. (2018), Identification of vanilloid compounds in grains of paradise and their effects on sympathetic nerve activity. J Sci Food Agric, 98: 4742-4748. doi:10.1002/jsfa.9009
- Ilic NM, Dey M, Poulev AA, Logendra S, Kuhn PE, Raskin I. Anti-inflammatory activity of grains of paradise (Aframomum melegueta Schum) extract. J Agric Food Chem. 2014;62(43):10452-7.
- THE THERMO HEAT® LOW-CARB MEDITERRANEAN DIET: WHY IT’S THE HEALTHIEST & BEST DIET FOR 2019 by Steve Blechman, https://advancedmolecularlabs.com/blogs/news/the-thermo-heat%C2%AE-low-carb-mediterranean-diet-why-it-s-the-healthiest-best-diet-for-2019
- The Thermo Heat® Weight Loss Revolution, by Michael J. Rudolph, Ph.D, including the foreword by Daniel L. Friedman, MD and Eugene B Friedman, MD.